Association of asymptomatic spinal cord lesions and atrophy with disability 5 years after a clinically isolated syndrome

Brownlee W. J.; Altmann D. R.; Da Mota P. Alves; Swanton J. K.; Miszkiel K. A.; Wheeler-Kingshott C. A. M. Gandini; Ciccarelli O.; Miller D. H.

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Association of asymptomatic spinal cord lesions and atrophy with disability 5 years after a clinically isolated syndrome

机译：临床上综合征后5年无症状脊髓病变与萎缩的关联

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摘要

Background: Spinal cord pathology is an important substrate for long-term disability in multiple sclerosis (MS).

机译：背景：脊髓病理学是多发性硬化症（MS）中长期残疾的重要基质。

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来源
《Multiple sclerosis: clinical and laboratory research》 |2017年第5期|共10页
作者
Brownlee W. J.; Altmann D. R.; Da Mota P. Alves; Swanton J. K.; Miszkiel K. A.; Wheeler-Kingshott C. A. M. Gandini; Ciccarelli O.; Miller D. H.;
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作者单位

UCL Inst Neurol Queen Sq Multiple Sclerosis Ctr Dept Neuroinflammat Box 112 London WC1N 3BG;

UCL Inst Neurol Queen Sq Multiple Sclerosis Ctr Dept Neuroinflammat Box 112 London WC1N 3BG;

UCL Inst Neurol Queen Sq Multiple Sclerosis Ctr Dept Neuroinflammat Box 112 London WC1N 3BG;

UCL Inst Neurol Queen Sq Multiple Sclerosis Ctr Dept Neuroinflammat Box 112 London WC1N 3BG;

Natl Hosp Neurol &

Neurosurg Lysholm Dept Neuroradiol London England;

UCL Inst Neurol Queen Sq Multiple Sclerosis Ctr Dept Neuroinflammat Box 112 London WC1N 3BG;

UCL Inst Neurol Queen Sq Multiple Sclerosis Ctr Dept Neuroinflammat Box 112 London WC1N 3BG;

UCL Inst Neurol Queen Sq Multiple Sclerosis Ctr Dept Neuroinflammat Box 112 London WC1N 3BG;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Clinically isolated syndrome; multiple sclerosis; MRI; spinal cord;

机译：临床上孤立的综合征;多发性硬化;MRI;脊髓;

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专利

1. Association of asymptomatic spinal cord lesions and atrophy with disability 5 years after a clinically isolated syndrome [J] . Brownlee W. J., Altmann D. R., Da Mota P. Alves, Multiple sclerosis: clinical and laboratory research . 2017,第5期

机译：临床上综合征后5年无症状脊髓病变与萎缩的关联
2. Brain atrophy and lesion load measures over 1 year relate to clinical status after 6 years in patients with clinically isolated syndromes. [J] . Di Filippo M, Anderson VM, Altmann D Journal of Neurology, Neurosurgery and Psychiatry . 2010,第2期

机译：对于患有临床孤立综合征的患者，超过1年的脑萎缩和病变负荷量与6年后的临床状况有关。
3. Spinal cord lesions: A modest contributor to diagnosis in clinically isolated syndromes but a relevant prognostic factor [J] . Georgina Arrambide, Alex Rovira, Jaume Sastre-Garriga, Multiple sclerosis: clinical and laboratory research . 2018,第3期

机译：脊髓病变：临床上综合征诊断的适度贡献者，但具有相关的预后因素
4. DORSAL ROOT IMPLANT ON LESIONED SPINAL CORD MORPHOLOGIC FINDINGS OF REGENERATION OF SYNAPSES IN THE MAMMALIAN SPINAL CORD-REPAIR AND RECOVERY [C] . C. C. Turbes Annual Rocky Mountain Bioengineering Symposium . 2003

机译：哺乳动物脊髓修复和恢复突变脊髓形态学发现的背根植入物
5. Inhibition of protein kinase C restores morphine efficacy following excitotoxic spinal cord injury: Implications for the treatment of post-spinal cord injury pain syndromes. [D] . Nolan, Todd Andrew. 2008

机译：抑制蛋白激酶C在兴奋性脊髓毒性损伤后恢复吗啡功效：对脊髓后损伤疼痛综合征的治疗意义。
6. Asymptomatic spinal cord lesions in clinically isolated opticnerve brain stem and spinal cord syndromes suggestive ofdemyelination [O] . J ORiordan, N Losseff, C Phatouros, 1998

机译：临床孤立的视神经无症状脊髓病变神经脑干和脊髓综合症提示脱髓鞘
7. Asymptomatic spinal cord lesions in clinically isolated optic nerve, brain stem, and spinal cord syndromes suggestive of demyelination [O] . O'Riordan, J, Losseff, N, Phatouros, C, 1998

机译：临床孤立的视神经无症状脊髓病变神经，脑干和脊髓综合症提示脱髓鞘

Association of asymptomatic spinal cord lesions and atrophy with disability 5 years after a clinically isolated syndrome

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