How gut transcriptional function of <i xmlns='http://www.wiley.com/namespaces/wiley'>Drosophila melanogasterDrosophila melanogaster varies with the presence and composition of the gut microbiota

Bost Alyssa; Franzenburg Soeren; Adair Karen L.; Martinson Vincent G.; Loeb Greg; Douglas Angela E.

摘要

Abstract > Despite evidence from laboratory experiments that perturbation of the gut microbiota affects many traits of the animal host, our understanding of the effect of variation in microbiota composition on animals in natural populations is very limited. The core purpose of this study on the fruit fly Drosophila melanogaster was to identify the impact of natural variation in the taxonomic composition of gut bacterial communities on host traits , with the gut transcriptome as a molecular index of microbiota‐responsive host traits. Use of the gut transcriptome was validated by demonstrating significant transcriptional differences between the guts of laboratory flies colonized with bacteria and maintained under axenic conditions. Wild Drosophila from six field collections made over two years had gut bacterial communities of diverse composition, dominated to varying extents by Acetobacteraceae and Enterobacteriaceae. The gut transcriptomes also varied among collections and differed markedly from those of laboratory flies. However, no overall relationship between variation in the wild fly transcriptome and taxonomic composition of the gut?microbiota was evident at all taxonomic scales of bacteria tested for both individual fly genes and functional categories in Gene Ontology. We conclude that the interaction between microbiota composition and host functional traits may be confounded by uncontrolled variation in both ecological circumstance and host traits (e.g., genotype, age physiological condition) under natural conditions, and that microbiota effects on host traits identified in the laboratory should, therefore, be extrapolated to field population with great caution. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“mec14413-abs-0001”xml：lang =“en”> <标题类型=“main” >摘要</标题> >尽管实验室实验证据了肠道微生物瘤的扰动影响动物宿主的许多特征，但我们对自然群体中动物变异的影响的理解非常有限。本研究对果蝇的核心目的果蝇Melanogaster </ i>是为了识别肠道组成的自然变化对肠道组成的自然变化对宿主特征的影响，</ i>与肠道转录组作为微生物群响应宿主性状的分子指数。通过展示用细菌定植的实验室苍蝇的肠道之间的显着转录差异并保持在轴烯条件下，验证了肠转录组的使用。狂野的果蝇</ i>从两年内完成的六个田间收集有肠道细菌社区的多种组合物，由乙酰丙酸酯和肠杆菌痤疮占不同的植物。肠道转录om也在收集中变化，并且从实验室苍蝇中显着不同。然而，在对基因本体中的单独飞基因和功能类别测试的所有细菌的所有分类尺度中，野生蝇转录组和肠道组成之间没有变异的整体关系。我们得出结论，Microbiota组成和宿主功能性质之间的相互作用可以通过生态环境和宿主特征（例如，基因型，年龄生理条件）在自然条件下的不受控制的变化来混淆，并且微生物群对实验室中确定的宿主性状的影响因此，谨慎地将其推断为野外群体。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-25253/'>《Molecular ecology》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bost Alyssa&option=202" target="_blank" rel="nofollow">Bost Alyssa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Franzenburg Soeren&option=202" target="_blank" rel="nofollow">Franzenburg Soeren;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Adair Karen L.&option=202" target="_blank" rel="nofollow">Adair Karen L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Martinson Vincent G.&option=202" target="_blank" rel="nofollow">Martinson Vincent G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Loeb Greg&option=202" target="_blank" rel="nofollow">Loeb Greg;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Douglas Angela E.&option=202" target="_blank" rel="nofollow">Douglas Angela E.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of EntomologyCornell UniversityIthaca NY USA;</p> <p>Department of EntomologyCornell UniversityIthaca NY USA;</p> <p>Department of EntomologyCornell UniversityIthaca NY USA;</p> <p>Department of BiologyUniversity of RochesterRochester NY USA;</p> <p>Department of EntomologyCornell UniversityIthaca NY USA;</p> <p>Department of EntomologyCornell UniversityIthaca NY USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1285.html" title="生态学（生物生态学）">生态学（生物生态学）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=16S rRNA gene amplicon&option=203" rel="nofollow">16S rRNA gene amplicon;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Acetobacteraceae&option=203" rel="nofollow">Acetobacteraceae;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=functional redundancy&option=203" rel="nofollow">functional redundancy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=germ‐free animals&option=203" rel="nofollow">germ‐free animals;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gnotobiotic&option=203" rel="nofollow">gnotobiotic;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microbiome&option=203" rel="nofollow">microbiome;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=transcriptomics&option=203" rel="nofollow">transcriptomics;</a> </p> <div class="translation"> 机译：16S rRNA基因扩增子;乙酰杆菌;功能冗余;无菌动物;gnotobiotic;微生物组;转录组织; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023742159.html">How gut transcriptional function of <i xmlns="http://www.wiley.com/namespaces/wiley">Drosophila melanogasterDrosophila melanogaster varies with the presence and composition of the gut microbiota</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bost Alyssa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bost Alyssa,</a> <a 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</span> <span> . 2020-07-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：提供者指导的个性化体重管理方法，包括营养成分和治疗性饮食技术，以改善体重管理中涉及的关键生理过程，即肠道微生物组成，肠道壁完整性，免疫功能，线粒体功能，营养状况，排毒，食欲调节，代谢激素，神经递质合成和神经发生。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023742159','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img 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How gut transcriptional function of Drosophila melanogasterDrosophila melanogaster varies with the presence and composition of the gut microbiota

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