Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma

摘要

PurposeThe purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-C-13]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM).ProceduresC-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-C-13]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA. Normalized lactate, pyruvate, total carbon, and lactate to pyruvate ratio from C-13 MRSI data were compared with normalized peak height and percent recovery of Delta R2* curve from the DSC images in the voxels containing tumor using a Pearson's linear correlation.ResultsNormalized peak height from DSC imaging showed substantial correlations with normalized lactate (r=0.6, p=0.02) and total carbon (r=0.6, p=0.02) from hyperpolarized C-13 MRSI data.ConclusionsSince the peak height in the Delta R2* curve from DSC data is related to the extent of blood volume, these hyperpolarized C-13 imaging parameters may be used to assess blood volume in rodent intracranial xenograft models of GBM.