Revisiting the role of Wnt/beta-catenin signaling in prostate cancer

摘要

The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/beta-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/beta-catenin pathway in prostate cancer and compel us to reexamine the interaction of the AR and Wnt/beta-catenin signaling pathways. This review includes newer areas of interest such as non-canonical Wnt signaling and the role of Wnts in prostate cancer stem cells. The effort to develop Wnt modulating therapeutics, both biologies and small molecules, is also discussed. (C) 2017 Elsevier B.V. All rights reserved.