Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

摘要

Herein we report the preparation of ammonium [~(11)C]thiocyanate via the reaction of [~(11)C]CS2 with ammonia. The [~(11)C]SCN? ion is demonstrated as a potent nucleophile that can be used to readily generate a range of ~(11)C-labelled thiocyanate molecules in high conversions. Furthermore, novel ~(11)C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones via an acid mediated cyclisation reaction.