Novel staging system using carbohydrate antigen (CA) 19-9 in extrahepatic cholangiocarcinoma and its implications on overall survival

摘要

Background: CA19-9 elevation has shown to be associated with poor prognosis in extrahepatic cholangiocarcinoma (ECCA). However, the role of CA19-9 in staging of ECCA has not been evaluated. We hypothesized that CA19-9 elevation is a marker of aggressive biology in ECCA and that inclusion of CA199 in the staging system may improve overall survival (OS) discrimination.