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Observation of curative effect of intravitreal injection of conbercept in wet age‐related macular degeneration: Optical coherence tomography analysis after injection

机译：湿性年龄相关性黄斑变性玻璃体内注射术治疗的疗效观察：注射后光学相干断层扫描分析

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Abstract > To observe the clinical efficacy of intravitreal injection of conbercept in the treatment of wet age‐related macular degeneration (wAMD), optical coherence tomography (OCT) and the best corrected visual acuity (BCVA) was observed to measure the changes of anatomical changes of central macular thickness (CMT) and the area and volume of retinal pigment epithelium (RPE) uplift. Fifteen patients (15 eyes) with wet AMD were enrolled in this study. All patients underwent intravitreal injection of conbercept of 0.05 mL once. After 1 week, 1 month, and 3 months, OCT and BCVA were used to examine and to compare with the preoperative and postoperative central macular thickness and RPE uplift area. BCVA (median) increased respectively from 0.12?±?0.13 to 0.21?±?0.15 at 1 week, to 0.90?±?0.25 at 1 month, to 0.38?±?0.17 at 3 months ( p ??.001). The thickness of central macular decreased from 500?±?25 μm to 256?±?19 μm, 221?±?29 μm, and 215?±?14 μm, respectively. The normal physiological structure and stratification of the macular area were clear gradually. Conbercept treatment of wet AMD can significantly improve visual acuity, after 1 month up to the plateau, 3 months of continuous drug injection can make the vision maintained at a high stage, and macular retinal normal structural morphology recovery is good, the treatment has no obvious adverse reactions, and with good security. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> >观察玻璃体内注射的临床疗效Conbercept在治疗湿年龄相关的黄斑变性（WAMD），光学相干断层扫描（OCT）和最佳校正的视力（BCVA），以测量中央黄斑厚度（CMT）和该区域的解剖变化的变化视网膜色素上皮（RPE）隆起的体积。本研究报告了十五名患者（15只眼）湿疗法。所有患者均接受玻璃体内注射0.05毫升的同胞。 1周后，1个月和3个月，OCT和BCVA用于检查并与术前和术后中央黄斑厚度和RPE隆起区域进行比较。 BCVA（中位数）分别从0.12？±0.13至0.21？±0.15至0.21？±0.15至0.90？±0.25，在1个月，至0.38？±0.17（ P </ i>） ？＆ 001）。中央黄斑的厚度从500？±25μm至256Ω·±19μm，221？±29μm，215？±14μm。黄斑地区的正常生理结构和分层逐渐清晰。 Conbercept治疗湿AMD可以显着改善视力，在1个月后到高原后，3个月的连续药物注射可以使视力保持在高阶段，而黄斑视网膜正常结构形态恢复良好，治疗没有明显不良反应，安全。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24994/'>《Microscopy research and technique》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Wen&option=202" target="_blank" rel="nofollow">Yang Wen;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tan Ying&option=202" target="_blank" rel="nofollow">Tan Ying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Chaowei&option=202" target="_blank" rel="nofollow">Li Chaowei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Yi&option=202" target="_blank" rel="nofollow">Liu Yi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Guohua&option=202" target="_blank" rel="nofollow">Lu Guohua;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bianchini Paolo&option=202" target="_blank" rel="nofollow">Bianchini Paolo;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of OphthalmologyThe Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical UniversityWujin District Changzhou 213164 China;</p> <p>Department of OphthalmologyThe Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical UniversityWujin District Changzhou 213164 China;</p> <p>Department of OphthalmologyThe Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical UniversityWujin District Changzhou 213164 China;</p> <p>Department of OphthalmologyThe Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical UniversityWujin District Changzhou 213164 China;</p> <p>Department of OphthalmologyThe Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical UniversityWujin District Changzhou 213164 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/19294.html" title="显微镜">显微镜;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=age‐related macular degeneration&option=203" rel="nofollow">age‐related macular degeneration;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=conbercept&option=203" rel="nofollow">conbercept;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OCT&option=203" rel="nofollow">OCT;</a> </p> <div class="translation"> 机译：年龄相关的黄斑变性;Conbercept;OCT; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> 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href="/conference-cn-2349/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 全国中医眼科名家学术研讨会 </a> <span> <span> . 2014</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315181204.html">玻璃体腔注射雷珠单抗治疗湿性年龄相关性黄斑变性的临床观察及疗效分析</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=耿超&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 耿超</a> <span> . 2019</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204335806.html">用于治疗干型和湿型年龄相关性黄斑变性或糖尿病视网膜病变的可注射的多孔装置</a> <b>[P]</b> . <span> 中国专利： CN107809977B </span> <span> . 2021.04.09</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120110299231.html">用于治疗干型和湿型年龄相关性黄斑变性或糖尿病视网膜病变的可注射的多孔装置</a> <b>[P]</b> . <span> 中国专利： CN107809977A </span> <span> . 2018-03-16</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130408036689.html">INTRAVITREAL INJECTION DEVICE AND BEVACIZUMAB, RANIBUZIMAB, BEVACUZIMAB, AFLIBERCEPT OR TRIAMCINOLONE FOR USE IN A METHOD OF PREVENTING, TREATING OR DELAYING MACULAR DEGENERATION OR MACULAR DIABETIC EDEMA</a> <b>[P]</b> . <span> 外国专利： <!-- 欧洲知识产权局专利： --> EP3324903A1 </span> <span> . 2018-05-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：静脉内注射装置和贝伐单抗，兰尼单抗，贝伐单抗，腹泻药或曲安西酮，用于预防，治疗或延缓黄斑变性或黄斑性糖尿病性乙二酰胺的方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130409289998.html">Intravitreal injection device and bevacizumab for use in a method of preventing, treating or delaying macular degeneration or macular diabetic edema.</a> <b>[P]</b> . <span> 外国专利： <!-- --> NL2015198B1 </span> <span> . 2017-02-07</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：玻璃体内注射装置和贝伐单抗用于预防，治疗或延迟黄斑变性或黄斑糖尿病性水肿的方法。 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130409003926.html">INTRAVITREAL INJECTION DEVICE AND BEVACIZUMAB, RANIBUZIMAB, BEVACUZIMAB, AFLIBERCEPT OR TRIAMCINOLONE FOR USE IN A METHOD OF PREVENTING, TREATING OR DELAYING MACULAR DEGENERATION OR MACULAR DIABETIC EDEMA</a> <b>[P]</b> . <span> 外国专利： <!-- 世界知识产权组织专利： --> WO2017014630A1 </span> <span> . 2017-01-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：静脉内注射装置和贝伐单抗，兰尼单抗，贝伐单抗，腹泻药或曲安西酮，用于预防，治疗或延缓黄斑变性或黄斑性糖尿病性乙二酰胺的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> 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