Synthesis of GalNGc alpha 1-3GalNAc alpha disaccharide and its interaction with human blood antibodies

摘要

We have synthesized GalNGc alpha 1-3GalNAc alpha disaccharide, a glycoloyl analogue of GalNAc alpha 1-3GalNAc alpha known as the core 5 motif of mucin-type glycoproteins, and investigated how this structural variation affects the interaction with human natural antibodies. In contrast to the case of the Neu5NGc/Neu5NAc pair, the additional glycoloyl OH group in GalNGc alpha 1-3GalNAc alpha markedly reduced the antigenicity of the GalNGc alpha moiety.