Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with ( <ce:italic>S</ce:italic>)-aspartic and ( <ce:italic>S</ce:italic>)-glutamic acids

Dmitry A. Gruzdev; Evgeny N. Chulakov; Galina L. Levit; Marionella A. Kravchenko; Victor P. Krasnov; Valery N. Charushin

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Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with ( S)-aspartic and ( S)-glutamic acids

机译：新型嘌呤-6-基-6-基-6-基-6-基 - 缀合物的合成和抗微生物活性（ s ） - 天冬和（ s ） - 谷氨酸

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Novel purine and 2-aminopurine conjugates containing fragments of (S)-aspartic and (S)-glutamic acids with free α-functional groups attachedviaa 1,2-ethylenediamine linker at 6-position of the purine core, as well as their analogues withN9-(2-hydroxyethoxy)methyl substituent have been synthesized. Among the conjugates obtained, compounds exhibiting a significant antimycobacterial activity have been found.

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显示省略含有碎片的新型嘌呤和2-氨基嘌呤缀合物（ s ） - 天冬和（ s ） - 具有自由α-官能团的谷氨酸通过 1,2-乙二胺连接器嘌呤核的6位，以及它们的类似物，以及它们的类似物：斜体> n 9 - （2-羟基乙氧基）甲基已合成取代基。在所得缀合物中，已经发现表现出显着的抗细管活性的化合物。 ]]>

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《Mendeleev Communications》 |2017年第6期|共3页
作者
Dmitry A. Gruzdev; Evgeny N. Chulakov; Galina L. Levit; Marionella A. Kravchenko; Victor P. Krasnov; Valery N. Charushin;
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I. Ya. Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences;

I. Ya. Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences;

I. Ya. Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences;

Ural Research Institute for Phthisiopulmonology;

I. Ya. Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences;

I. Ya. Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences;

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机译：新型嘌呤-6-基-6-基-6-基-6-基 - 缀合物的合成和抗微生物活性（ s ） - 天冬和（ s ） - 谷氨酸
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Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with ( S)-aspartic and ( S)-glutamic acids

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