Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne

Guranova Natalia I.; Varlamov Alexey V.; Ilyushenkova Valentina V.; Sokolova Ekaterina A.; Borisova Tatiana N.; Aksenov Alexander V.; Khrustalev Viktor N.; Voskressensky Leonid G.

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Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne

机译：3,4-二羟基喹啉和二氢噻吩的反应[3,2-C]吡啶与苯并尼

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摘要

Cyanomethyl-substituted tetrahydroisoquinolines and tetrahydrothieno[3,2-c]pyridines were synthesized by multicomponent reaction of the dihydro analogues of aforesaid systems with benzyne and acetonitrile. The products obtained relate to alkaloids of isoquinoline family of 1,2,3,4-tetrahydro level.

机译：通过与苯齐尼和乙腈的二氢体体系的二氢类似物的多组分反应合成氰基甲基取代的四氢异喹啉和四氢噻吩[3,2-C]吡啶。获得的产品涉及异喹啉家族的生物碱，其1,2,3,4-四核水平。

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《Mendeleev Communications 》 |2017年第5期| 共3页
作者
Guranova Natalia I.; Varlamov Alexey V.; Ilyushenkova Valentina V.; Sokolova Ekaterina A.; Borisova Tatiana N.; Aksenov Alexander V.; Khrustalev Viktor N.; Voskressensky Leonid G.;
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RUDN Univ Dept Organ Chem Moscow 117198 Russia;

RUDN Univ Dept Organ Chem Moscow 117198 Russia;

RUDN Univ Dept Organ Chem Moscow 117198 Russia;

RUDN Univ Dept Organ Chem Moscow 117198 Russia;

RUDN Univ Dept Organ Chem Moscow 117198 Russia;

North Caucasus Fed Univ Stavropol 355009 Russia;

RUDN Univ Dept Organ Chem Moscow 117198 Russia;

RUDN Univ Dept Organ Chem Moscow 117198 Russia;

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1. Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne [J] . Guranova Natalia I., Varlamov Alexey V., Ilyushenkova Valentina V., Mendeleev Communications . 2017 ,第5期

机译：3,4-二羟基喹啉和二氢噻吩的反应[3,2-C]吡啶与苯并尼
2. Condensed Pyridine Bases. Synthesis and Reactions of Benzofuro[2,3-c]indeno[2,1-e]-, Benzothieno[2,3-c]Indeno[2,1-e]-, Benzofuro-[3,2-c]Indeno[2,1-e]- and Thieno[2,3:4′,5′]-thieno[3,2-c]indeno[2,1-e]pyridines [J] . S. V. Tolkunov, A. I. Khyzhan, S. Yu. Suikov, Chemistry of heterocyclic compounds . 2005 ,第3期

机译：缩合吡啶碱。苯并呋喃[2,3-c]茚并[2,1-e]-，苯并噻吩并[2,3-c]茚并[2,1-e]-，苯并呋喃[3,2-c]-茚并的合成与反应[2,1-e]-和噻吩并[2,3：4'，5']-噻吩并[3,2-c]茚并[2,1-e]吡啶
3. Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines [J] . Lanyon-Hogg Thomas, Ritzefeld Markus, Masumoto Naoko, The Journal of Organic Chemistry . 2015 ,第9期

机译：5-酰胺-6,7-二氢噻吩并[3,2-c]吡啶中酰胺键旋转体的调节
4. A Novel One-Pot Five-Component Synthesis of Tetrahydro-pyrrolo3,4-b pyridine-5-one via Ugi/Aza-Diels-Alder Tandem Reaction [C] . Yan Liu, Tianyi Shang, Chuanming Xu, International conference on applied biotechnology . 2015

机译：通过Ugi / Aza-Diels-Alder串联反应合成新颖的一锅五组分四氢吡咯并3,4-b吡啶-5-酮
5. Synthesis, application, and mechanistic studies of the asymmetric addition of organozinc reagents to 3,4-dihydroisoquinoline N-oxide. [D] . Wang, Sa. 2010

机译：有机锌试剂不对称加成到3,4-二氢异喹啉N-氧化物中的合成，应用和机理研究。
6. Reactions of HDDA-derived Benzynes with Sulfides: Mechanism Modes and Three-component Reactions [O] . Junhua Chen, Vignesh Palani, Thomas R. Hoye -1

机译：HDDA衍生的硫化氢与硫化物的反应：机理方式和三组分反应
7. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase [O] . Lanyon-Hogg, T, Masumoto, N, Bodakh, G, 2016

机译：刺猬酰基转移酶的5-酰基-6,7-二氢噻吩并[3,2-c]吡啶抑制剂的合成与表征

Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne

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