首页> 外文期刊>Microchemical Journal: Devoted to the Application of Microtechniques in all Branches of Science >Deep eutectic solvent as a novel disperser in dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFOD) for preconcentration of steroids in water samples: Assessment of the method deleterious impact on the environment using Analytical Eco-Scale and Green Analytical Procedure Index
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Deep eutectic solvent as a novel disperser in dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFOD) for preconcentration of steroids in water samples: Assessment of the method deleterious impact on the environment using Analytical Eco-Scale and Green Analytical Procedure Index

机译:基于浮动有机液滴(DLLME-SFOD)的浮动有机液滴(DLLME-SFOD)凝固的新型分散器,用于水样中类固醇的前浓度:使用分析生态规模和绿色分析评估方法对环境的有害影响的评估 程序索引

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Herein, we seek clues to investigate the effectiveness of deep eutectic solvent (DES) as a novel dispersive solvent in DLLME-SFOD for the enrichment of nine steroids in water for the first time. The novel DLLME-SFOD method is premised on using 2-dodecanol as extractant and DES (tetrabutylammonium bromide: acetic acid) as a dispersive solvent. Using DES as disperser was compared with other conventional dispersers like (ethanol, methanol, and acetone) attaining a higher recovery than the conventional dispersers. Both HPLC-DAD separation and DLLME-SFOD procedure were optimized by one-factor-at-a-time (OFAT) succeeded by experimental design applying response surface methodology (RSM) to check the optimal conditions of both HPLC separation and extraction. Under the optimal conditions, the proposed method revealed good linearity (correlation coefficients >= 0.998), low detection limits (in the range of 1.0-9.7 ng/mL), and high inter- and intra-day precision (%RSD < 5) with high preconcentration factors in the ranges of (44-112) for the nine concerned steroids. Moreover, the method was successfully applied to determine the concerned steroids in different real aqueous samples with expanded measurement uncertainty of the results < 17% at 95% confidence level. Finally, the developed procedure impact on the environment was assessed by applying the Analytical Eco-Scale and Green Analytical Procedure Index (GAPI) tools, proving the greenness of the method. The novel disperser DESs have the merits of simple preparation, low cost, enhancing extraction efficiency and being eco-friendly. These DESs can be used to replace conventional organic disperser solvents.
机译:在此,我们寻求线索以研究深红色溶剂(DES)作为DLLME-SFOD中的一种新型分散溶剂的有效性,首次富集水中九个类固醇。使用2-十二烷醇作为萃取剂和DES(四丁基溴化铵:乙酸)作为分散溶剂的新型DLLME-SFOD方法。将DES DES分散器与诸如(乙醇,甲醇和丙酮)的其他常规分散器进行比较,其恢复比常规分散器更高。通过实验设计施加响应面方法(RSM)成功地通过单因素 - AT-A-AT-A-Time(OFAT)进行优化HPLC-DAD分离和DLLME-SFOD程序,以检查HPLC分离和提取的最佳条件。在最佳条件下,所提出的方法揭示了良好的线性度(相关系数> = 0.998),低检测限(1.0-9.7ng / ml的范围内),以及最高的和日内综合精度(%RSD <5)在九个有关类固醇的范围内具有高预浓度因子。此外,该方法已成功应用于确定不同实际水性样品中的有关类固醇,其结果的膨胀测量不确定度<17%在95%的置信水平下。最后,通过应用分析生态级和绿色分析程序指数(Gapi)工具来评估对环境的发达的程序影响,从而证明该方法的绿色。新型Disperser Dess具有简单的制备,成本低,提高提取效率和环保的优点。这些DES可用于取代常规的有机分散器溶剂。

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