Systemic PPAR gamma deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility

摘要

Background: The peroxisome proliferator-activated receptory gamma (PPAR gamma) is a ligand-dependent transcription factor involved in many aspects of metabolism, immune response and development. Numerous studies relying on tissue-specific invalidation of the Pparg gene have shown distinct facets of its activity, whereas the effects of its systemic inactivation remain unexplored due to embryonic lethality. By maintaining PPAR gamma expression in the placenta, we recently generated a mouse model carrying Pparg full body deletion (Pparg(Delta/Delta)), which in contrast to a previously published model is totally deprived of any form of adipose tissue. Herein, we propose an in-depth study of the metabolic alterations observed in this new model.