Synthesis and Biological Evaluation of Novel 2 3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents

Coaviche-Yoval Arturo; Luna Hector; Tovar-Miranda Ricardo; Soriano-Ursua Marvin A.; Trujillo-Ferrara Jose G.

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Synthesis and Biological Evaluation of Novel 2 3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents

机译：GABA新三二取代的苯并呋喃类似物作为神经疗递生物的合成与生物学评价

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摘要

Background: Benzofurans are heterocyclic compounds with neurotropic activity. Some have been developed for the treatment of acute and degenerative neuronal injuries.

机译：背景：苯并呋喃是具有神经渗透活性的杂环化合物。有些是为治疗急性和退行性神经元损伤而开发的。

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来源
《Medicinal chemistry》 |2019年第1期|共10页
作者
Coaviche-Yoval Arturo; Luna Hector; Tovar-Miranda Ricardo; Soriano-Ursua Marvin A.; Trujillo-Ferrara Jose G.;
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作者单位

Univ Autonoma Metropolitana Dept Sistemas Biol Campus Xochimilco Calzada Hueso 1100 Mexico City;

Univ Autonoma Metropolitana Dept Sistemas Biol Campus Xochimilco Calzada Hueso 1100 Mexico City;

Univ Veracruzana Inst Ciencias Basicas Av Dr Luis Castelazo Ayala S-N Col Ind Animas Xalapa;

Inst Politecn Nacl Escuela Super Med Plan San Luis &

Diaz Miran S-N Col Casco Santo Mexico City;

Inst Politecn Nacl Escuela Super Med Plan San Luis &

Diaz Miran S-N Col Casco Santo Mexico City;

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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
2; 3-disubstituted benzofurans (BZF); molecular docking; GABA receptor (GABA-R); seizures; pentylenetetrazol (PTZ); 4-aminopyridine (4-AP);

机译：2;3二取代的苯并呋喃（BZF）;分子对接;GABA受体（GABA-R）;癫痫发作;五苯甲酸四唑（PTZ）;4-氨基吡啶（4-AP）;

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1. Synthesis and Biological Evaluation of Novel 2 3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents [J] . Coaviche-Yoval Arturo, Luna Hector, Tovar-Miranda Ricardo, Medicinal chemistry . 2019,第1期

机译：GABA新三二取代的苯并呋喃类似物作为神经疗递生物的合成与生物学评价
2. Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents [J] . Cogo Juliana, Kaplum Vanessa, Sangi Diego Pereira, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2015,第Null期

机译：新型2,3-二取代喹喔啉衍生物的合成及生物学评价作为抗疟药和抗锥虫药
3. Synthesis, biological evaluation and molecular dynamic simulations of novel Benzofuran-tetrazole derivatives as potential agents against Alzheimer’s disease [J] . Pragati Kushwaha, Soobiya Fatima, Akanksha Upadhyay, Bioorganic and Medicinal Chemistry Letters . 2019,第1期

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4. Synthesis and biological evaluation of resveratrol analogues as anti-bacterial agents [C] . Rui Cao, Lu Bai, Na Ji, IT in Medicine and Education (ITME), 2011 International Symposium on . 2011

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5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

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6. Synthesis characterization molecular docking studies and biological evaluation of some novel hybrids based on quinazolinone benzofuran and imidazolium moieties as potential cytotoxic and antimicrobial agents [O] . Parvin Asadi, Ghadamali Khodarahmi, Ali Jahanian-Najafabadi, 2017

机译：某些基于喹唑啉酮苯并呋喃和咪唑鎓部分作为潜在细胞毒性和抗菌剂的新型杂种的合成表征分子对接研究和生物学评估
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Synthesis and Biological Evaluation of Novel 2 3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents

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