Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene

Toumpeki Chrisavgi; Anastasakis Dimitrios; Panagoulias Ioannis; Stamatopoulou Vassiliki; Georgakopoulos Tassos; Kallia-Raftopoulos Sofia; Mouzaki Athanasia; Drainas Denis

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Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene

机译：用于靶向和快速mRNA切割的M1GS核酶的构建; 在ETS-2癌基因上的应用

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Background: RNase P-mediated cleavage of target RNAs has been proposed as a promising tool for gene silencing. Ets-2 proto-oncogene controls the expression of a wide variety of genes involved in cancer and immunity.

机译：背景：已经提出了靶RNA的RNase P介导的裂解作为基因沉默的有希望的工具。 ETS-2原癌基因对癌症和免疫涉及癌症和免疫的各种基因的表达。

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来源
《Medicinal chemistry》 |2018年第6期|共13页
作者
Toumpeki Chrisavgi; Anastasakis Dimitrios; Panagoulias Ioannis; Stamatopoulou Vassiliki; Georgakopoulos Tassos; Kallia-Raftopoulos Sofia; Mouzaki Athanasia; Drainas Denis;
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作者单位

Univ Patras Sch Med Dept Biol Chem Patras 26500 Greece;

Univ Patras Sch Med Dept Biol Chem Patras 26500 Greece;

Univ Patras Sch Med Dept Internal Med Div Hematol Patras 26500 Greece;

Univ Patras Sch Med Dept Biol Chem Patras 26500 Greece;

Univ Patras Sch Med Dept Internal Med Div Hematol Patras 26500 Greece;

Univ Patras Sch Med Dept Biol Chem Patras 26500 Greece;

Univ Patras Sch Med Dept Internal Med Div Hematol Patras 26500 Greece;

Univ Patras Sch Med Dept Biol Chem Patras 26500 Greece;

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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
RNase P; spiramycin; gene silencing; cytokines; IFN-alpha; IL-2; IL-4; IL-10;

机译：RNase p;spiramycin;基因沉默;细胞因子;IFN-alpha;IL-2;IL-4;IL-10;

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1. Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene [J] . Toumpeki Chrisavgi, Anastasakis Dimitrios, Panagoulias Ioannis, Medicinal chemistry . 2018,第6期

机译：用于靶向和快速mRNA切割的M1GS核酶的构建; 在ETS-2癌基因上的应用
2. In Vitro Construction of Effective M1GS Ribozymes Targeting HCMV UL54 RNA Segments [J] . Yun-Zhen SU, Hong-Jian LI, Yue-Qin LI, 生物化学与生物物理学报：英文版 . 2005,第003期

机译：靶向HCMV UL54 RNA片段的有效M1GS核酶的体外构建
3. Site-specific cleavage of oncogene Ki-ras mRNA by ribozyme in vitro [J] . 方裕强, 许国铭, 李兆申, 中国人民解放军军医大学学报：英文版 . 1999,第001期

机译：核酶体外亚丙烯Ki-ras mRNA的特异性特异性切割
4. Supervised method for construction of microRNA-mRNA networks: Application in cardiac tissue aging dataset [C] . Dimitrakopoulos Georgios N., Dimitrakopoulou Konstantina, Maraziotis Ioannis A., Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：microRNA-mRNA网络构建的监督方法：在心脏组织衰老数据集中的应用
5. Part I: Ring-Rearrangement Metathesis of Himbert Arene-Allene Cycloadducts for the Rapid, Modular Construction of Complex Molecular Scaffolds. Part II: Application of Zincke Aldehydes Toward the Synthesis of Gelsemine. [D] . Lam, Jonathan K. 2014

机译：第一部分：Himbert Arene-Allene缩合物的环重排易位，用于复杂分子支架的快速，模块化构建。第二部分：锌醛在胶体明胶合成中的应用。
6. Expression of a chimeric ribozyme gene results in endonucleolytic cleavage of target mRNA and a concomitant reduction of gene expression in vivo. [O] . P Steinecke, T Herget, P H Schreier 1992

机译：嵌合核酶基因的表达导致靶mRNA的内切核酸酶裂解并伴随体内基因表达的减少。
7. In Vitro Construction of Effective M1GS Ribozymes Targeting HCMV UL54 RNA Segments [O] . Yun-zhen Su, Hong-jian Li, Yue-qin Li, 2015

机译：靶向HCmV UL54 RNa片段的有效m1Gs核酶的体外构建
8. Inactivation of FGF Receptors by Targeting Ribozymes Against FGFR mRNAs and Their Effect on FGF Dependent In Vitro and In Vivo Breast Cancer Growth Phenotypes [R] . Estes, N. R. 2004

机译：通过靶向针对FGFR mRNa的核酶对FGF受体的灭活及其对FGF依赖的体外和体内乳腺癌生长表型的影响

Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene

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