Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt's Lymphoma

Byrne Andrew J.; Bright Sandra A.; Fayne Darren; McKeown James P.; McCabe Thomas; Twamley Brendan; Williams Clive; Meegan Mary J.

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Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt's Lymphoma

机译：硝基苯甲酯和相关化合物在Burkitt的淋巴瘤中的合成，抗增殖和促细胞凋亡作用

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Background: Cancers of the lymphatic cells (lymphomas) account for approximately 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt's lymphoma (BL).

机译：背景：淋巴细胞（淋巴瘤）的癌症占全球恶性疾病的约12％。将硝基rene支架被鉴定为铅靶结构，用于靶向Burkitt淋巴瘤（BL）的特别有效的化合物。

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来源
《Medicinal chemistry》 |2018年第2期|共19页
作者
Byrne Andrew J.; Bright Sandra A.; Fayne Darren; McKeown James P.; McCabe Thomas; Twamley Brendan; Williams Clive; Meegan Mary J.;
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作者单位

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Pharm &

Pharmaceut Sci 152-160 Pearse St Dublin;

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Biochem &

Immunol 152-160 Pearse St Dublin 2;

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Biochem &

Immunol 152-160 Pearse St Dublin 2;

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Pharm &

Pharmaceut Sci 152-160 Pearse St Dublin;

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Chem Dublin Ireland;

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Chem Dublin Ireland;

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Biochem &

Immunol 152-160 Pearse St Dublin 2;

Trinity Coll Dublin Trinity Biomed Sci Inst Sch Pharm &

Pharmaceut Sci 152-160 Pearse St Dublin;

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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
Anticancer agent; B cell; Burkitt's lymphoma; DG-75; MUTU-1; 3-Nitro-2-pheny-2H-chromene; nitrostyrene;

机译：抗癌剂;B细胞;Burkitt的淋巴瘤;DG-75;mutu-1;3-硝基-2-苯基-2h-铬;硝基丁烯;

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专利

1. Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt's Lymphoma [J] . Byrne Andrew J., Bright Sandra A., Fayne Darren, Medicinal chemistry . 2018,第2期

机译：硝基苯甲酯和相关化合物在Burkitt的淋巴瘤中的合成，抗增殖和促细胞凋亡作用
2. The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters. [J] . Cloonan SM, Drozgowska A, Fayne D, Leukemia and lymphoma . 2010,第3期

机译：抗抑郁药马普替林和氟西汀与去甲肾上腺素和5-羟色胺转运蛋白无关，对伯基特淋巴瘤具有有效的选择性抗增殖作用。
3. Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells [J] . Roberta Cariati, Paola Zancai, Elisabetta Righetti, Oncogene . 2003,第6期

机译：氧化磷酸化的抑制下来了Mofarotene（RO 40-8757）在Burkitt的淋巴瘤细胞中的抗增殖和凋亡作用
4. Potency Fraction Ethyl Acetat of Myrmecodia pendans Merr Perry On Apoptosis Induction of malignant Burkitt's Lymphoma Oral Cell In Vitro [C] . Ana Medawati, Supriatno, Sofia Mubarika, International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research . 2019

机译：Myrmecodia pendans Merr＆Perry对Matignant Burkitt在体外凋亡诱导的效力分数
5. Reactivation of Epstein-Barr Virus in Burkitt Lymphoma Cells in Response to Histone Deacetylase Inhibitors [D] . Daigle, Derek Alan 2011

机译：响应组蛋白脱乙酰基酶抑制剂的伯基特淋巴瘤细胞中爱泼斯坦-巴尔病毒的重新激活。
6. Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitts lymphoma B cells [O] . Gorbatchev Ambroise, Alain Portier, Nathalie Roders, 2015

机译：PUMA的亚细胞定位调节其在伯基特氏淋巴瘤B细胞中的促凋亡活性
7. Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells [O] . CARIATI R., ZANCAI P., RIGHETTI E., 2003

机译：氧化磷酸化的抑制作用是莫法罗汀（Ro 40-8757）在伯基特淋巴瘤细胞中的抗增殖和凋亡作用

Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt's Lymphoma

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