IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Anti-inflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

摘要

Background: 3,3'-Diindolylmethane (DIM) is a condensation product of indole-3-carbinol, a glucosinolate naturally occurring in Brassica genus vegetables. The antiinflammatory properties of DIM through the inhibition of NF-kappa B, as well as its ameliorating effects on glucose tolerance and hyperglicemic states, have been described. A subclinical proinflammatory profile resultant from the interaction of adipocytes and macrophages has been reported in obesity, affecting the insulin signaling pathway, contributing to insulin resistance.