Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents

Bognar Balazs; Kuppusamy M. Lakshmi; Madan Esha; Kalai Tamas; Balog Maria; Jeko Jozsef; Kuppusamy Periannan; Hideg Kalman

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Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents

机译：姜黄素 - 硝基氧化物的分子杂交种作为抗氧化剂和抗增殖剂的合成与生物学评价

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Background: Natural products and their derivatives are widely used to treat cancer and other diseases associated with ROS- and RNS-induced damages.

机译：背景：天然产品及其衍生物被广泛用于治疗癌症和与ROS和RNS引起的损害相关的癌症和其他疾病。

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来源
《Medicinal chemistry》 |2017年第8期|共12页
作者
Bognar Balazs; Kuppusamy M. Lakshmi; Madan Esha; Kalai Tamas; Balog Maria; Jeko Jozsef; Kuppusamy Periannan; Hideg Kalman;
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作者单位

Univ Pecs Inst Organ &

Med Chem Szigeti St 12 H-7624 Pecs Hungary;

Dartmouth Coll Geisel Sch Med Dept Radiol Rubin 601 One Med Ctr Dr Lebanon NH 03756 USA;

Dartmouth Coll Geisel Sch Med Dept Radiol Rubin 601 One Med Ctr Dr Lebanon NH 03756 USA;

Univ Pecs Inst Organ &

Med Chem Szigeti St 12 H-7624 Pecs Hungary;

Univ Pecs Inst Organ &

Med Chem Szigeti St 12 H-7624 Pecs Hungary;

Coll Nyiregyhaza Dept Chem Sostoi St 31-B H-4440 Nyiregyhaza Hungary;

Dartmouth Coll Geisel Sch Med Dept Radiol Rubin 601 One Med Ctr Dr Lebanon NH 03756 USA;

Univ Pecs Inst Organ &

Med Chem Szigeti St 12 H-7624 Pecs Hungary;

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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
Antioxidants; anti-proliferative compounds; curcuminoids; nitroxides; Pabon reaction; structure-activity relationship;

机译：抗氧化剂;抗增殖化合物;姜黄素;硝基氧化物;PABON反应;结构 - 活动关系;

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1. Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents [J] . Bognar Balazs, Kuppusamy M. Lakshmi, Madan Esha, Medicinal chemistry . 2017,第8期

机译：姜黄素 - 硝基氧化物的分子杂交种作为抗氧化剂和抗增殖剂的合成与生物学评价
2. Synthesis, biological evaluation, and molecular modeling studies of novel heterocyclic compounds as anti-proliferative agents [J] . Anurag Chaudhary, P. P. Sharma, Gautam Bhardwaj, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2013,第12期

机译：新型杂环化合物作为抗增殖剂的合成，生物学评估和分子建模研究
3. Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, A beta(1-42) aggregation inhibitors and metal-chelating agents for Alzheimer's disease [J] . Xu Ping, Zhang Minkui, Sheng Rong, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2017,第期

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4. Synthesis and Biological Evaluation of the novel Antioxidant Agent Quercetin Derivatives [C] . Xin Qu, Hongye Zhao, Dan Wu, International Conference on Material, Mechanical and Manufacturing Engineering . 2015

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5. Design, synthesis, biological evaluation and molecular modeling of novel taxane-based anticancer agents and paclitaxel mimics. [D] . Sun, Liang. 2008

机译：新型紫杉烷类抗癌药和紫杉醇模拟物的设计，合成，生物学评估和分子建模。
6. Synthesis characterization molecular docking studies and biological evaluation of some novel hybrids based on quinazolinone benzofuran and imidazolium moieties as potential cytotoxic and antimicrobial agents [O] . Parvin Asadi, Ghadamali Khodarahmi, Ali Jahanian-Najafabadi, 2017

机译：某些基于喹唑啉酮苯并呋喃和咪唑鎓部分作为潜在细胞毒性和抗菌剂的新型杂种的合成表征分子对接研究和生物学评估
7. Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents [O] . Kazunobu Toshima, Masashi Hasegawa, Junji Shimizu, 2004

机译：蒽 - 碳水化合物杂化物的分子设计，化学合成和生物学评价，作为新型DNa光染和光选细胞毒剂

Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents

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