The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation

Skonieczna Magdalena; Cieslar-Pobuda Artur; Saenko Yuriy; Foksinski Marek; Olinski Ryszard; Rzeszowska-Wolny Joanna; Wiechec Emilia

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The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation

机译：诱导的抑制电压依赖性阴离子通道（VDAC）对淋巴细胞细胞对电离辐射的细胞响应的影响

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Background: The voltage-dependent anion channels (VDAC) play an essential role in the cross talk between mitochondria and the rest of the cell. Their implication in cell life and cell death has been studied extensively in recent years. In this work we studied the impact of mitochondrial membrane (VDACs) on cell survival and response to X-ionizing radiation (IR) of human lymphoblastoid K562 cells.

机译：背景：电压依赖性阴离子通道（VDAC）在线粒体和其余细胞之间的交叉谈话中起重要作用。近年来，他们对细胞生命和细胞死亡的含义已经过广泛研究。在这项工作中，我们研究了线粒体膜（VDACS）对人淋巴细胞K562细胞X电离辐射（IR）的影响和对X电离辐射（IR）的影响。

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来源
《Medicinal chemistry》 |2017年第5期|共7页
作者
Skonieczna Magdalena; Cieslar-Pobuda Artur; Saenko Yuriy; Foksinski Marek; Olinski Ryszard; Rzeszowska-Wolny Joanna; Wiechec Emilia;
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作者单位

Silesian Tech Univ Inst Automat Control Akad 16 PL-44100 Gliwice Poland;

Silesian Tech Univ Inst Automat Control Akad 16 PL-44100 Gliwice Poland;

Ulyanovsk State Univ SP Kapitsa Technol Res Inst Lab Mol &

Cell Biol Lva Tolstogo 42 Ulyanovsk;

Nicolaus Copernicus Univ Torun Fac Pharm Coll Med Bydgoszcz Dept Clin Biochem Karlowicza 24 PL;

Nicolaus Copernicus Univ Torun Fac Pharm Coll Med Bydgoszcz Dept Clin Biochem Karlowicza 24 PL;

Silesian Tech Univ Inst Automat Control Akad 16 PL-44100 Gliwice Poland;

Linkoping Univ Dept Clin &

Expt Med IKE Div Cell Biol S-58185 Linkoping Sweden;

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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
4; 4' -diisothiocyanostilbene-2; 2' -disulfonic acid (DIDS); voltage-dependent anion channel (VDAC); reactive oxygen species (ROS); ionizing radiation; cell death; DNA strand breaks;

机译：4;4'-二异噻唑替尔替苯-2;2'-二硫酸（DIDS）;电压依赖性阴离子通道（VDAC）;活性氧（ROS）;电离辐射;细胞死亡;DNA链断裂;

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1. The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation [J] . Skonieczna Magdalena, Cieslar-Pobuda Artur, Saenko Yuriy, Medicinal chemistry . 2017,第5期

机译：诱导的抑制电压依赖性阴离子通道（VDAC）对淋巴细胞细胞对电离辐射的细胞响应的影响
2. All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain [J] . Cesar MD., Wilson JE. Archives of Biochemistry and Biophysics . 2004,第2期

机译：电压依赖性阴离子通道的所有三种同工型（VDAC1，VDAC2和VDAC3）存在于牛，兔和大鼠脑的线粒体中
3. Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death [J] . N Rimmerman, D Ben-Hail, Z Porat, Cell death & disease. . 2013,第12期

机译：大麻二酚直接调节外部线粒体膜通道，电压依赖性阴离子通道1（VDAC1）：大麻素诱导的细胞死亡的新机制
4. Quantifying the Effects of Ionizing Radiation and Radiprotectors on Lymphoblastoid Cells using OFFGeLC-MS~(E). [C] . Jonathan Erde, A. Jimmy Ytterberg, Shareef A. Nahas, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用偏心-MS〜（e）量化电离辐射和辐射调节对淋巴细胞细胞的影响。
5. Responses to ionizing radiation and translation inhibition in Drosophila melanogaster and human cancer cells. [D] . Stickel, Stefanie Michaela. 2014

机译：果蝇和人类癌细胞对电离辐射和翻译抑制的反应。
6. Direct modulation of the outer mitochondrial membrane channel voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death [O] . N Rimmerman, D Ben-Hail, Z Porat, 2013

机译：大麻二酚直接调节外部线粒体膜通道电压依赖性阴离子通道1（VDAC1）：大麻素诱导的细胞死亡的新机制
7. The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation [O] . Magdalena Skonieczna, Artur Cieslar-Pobuda, Yuriy Saenko, 2017

机译：诱导的抑制抑制电压依赖性阴离子通道（VDAC）对淋巴细胞细胞对电离辐射的细胞响应的影响

The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation

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