Neuropharmacological Screening of Chiral and Non-chiral Phthalimide-Containing Compounds in Mice: in vivo and in silico Experiments

摘要

Background: Thalidomide, the first synthesized phthalimide, has demonstrated sedative-hypnotic and antiepileptic effects on the central nervous system. N-substituted phthalimides have an interesting chemical structure that confers important biological properties.