Design, Synthesis and In Vitro Evaluation of Novel Anti-HIV 3-Pyrazol-3-yl-Pyridin-2-One Analogs

摘要

Background: Natural products have shown potent anti-HIV activity, but some of these also possess toxicity. The pharmacophoric fragments of these natural products have scope of combination with other pharmacophoric fragment and derivatization to reduce toxicity and increase the potency. Combination of natural product fragments from different classes of anti-HIV compounds may lead to a new class of potent anti-HIV agents.