Effectiveness and safety of aspirin after total hip or knee replacement

摘要

Almost all patients who undergo total hip replacement or total knee replacement receive aspirin or other antithrombotic agents to lower risk for venous thromboembolism (VTE). Practice guidelines vary in their recommendations by procedure and by country. For this meta-analysis, researchers identified 13 randomised controlled trials (with 6060 patients) in which aspirin was compared with low-molecular-weight heparin, rivaroxaban or warfarin after total hip replacement (seven studies), total knee replacement (three studies) or both (three studies). Duration of antithrombotic therapy ranged from seven to 42 days.