The radioprotective effect of caffeic acid phenethyl ester in the brain tissue of total head irradiated rats

摘要

In this study, we evaluated if caffeic acid phenethyl ester (CAPE) has protective effect on the damage in brain tissue induced by gamma radiation applied to rats, considering that may have inhibitory effects on ionizing radiation damage. To this end, 36 Male Wistar-Albino rats were used in our study. Our study groups are consisted of 4 subgroups: 2 control, radiotherapy (R), and KAFE + R. All of the groups except the control received a single dose of 5 Gy of radiotherapy on the first day. On day 11, brain tissues of all rats were removed and homogenized in phosphate buffer. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxanase (PON), arylesterase (ARE), ceruloplasmin (SER) and total sulfhydryl (SH) parameters were measured to determine if CAFE has protective effect. In conclusion, ARE, PON activities and total SH levels were statistically increased compared to the group R and LOOH, TOS and OSI levels significantly decreased. In conclusion, our findings show that CAFE might be having antioxidative effects to oxidative damage induced by radiation in brain of rats. However, to be confirmed these findings, it is needed to be supported by pharmacological and toxicological studies.