Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

Zhou Jingying; Liu Man; Sun Hanyong; Feng Yu; Xu Liangliang; Chan Anthony W. H.; Tong Joanna H.; Wong John; Chong Charing Ching Ning; Lai Paul B. S.; Wang Hector Kwong-Sang; Tsang Shun-Wa; Goodwin Tyler; Liu Rihe; Huang Leaf; Chen Zhiwei; Sung Joseph J. Y.; Chow King Lau; To Ka Fai; Cheng Alfred Sze-Lok

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Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

机译：肝癌内在CCRK抑制减少了骨髓衍生的抑制细胞免疫抑制，增强了免疫检查点阻滞效力

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Objective Myeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. Emerging evidence highlights the pivotal functions of cyclin-dependent kinases (CDKs) in tumour immunity. Here we elucidated the role of tumour-intrinsic CDK20, or cell cycle-related kinase (CCRK) on immunosuppression in hepatocellular carcinoma (HCC).

机译：目的霉菌衍生的抑制细胞（MDSC）有助于肿瘤免疫抑制微环境和免疫检查点抗抗性。新兴的证据突出了细胞周期蛋白依赖性激酶（CDKS）在肿瘤免疫中的关键功能。在这里，我们阐明了肿瘤内在CDK20或细胞周期相关激酶（CCRK）对肝细胞癌（HCC）免疫抑制的作用。

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来源
《Fortschritte der Physik》 |2018年第5期|共14页
作者
Zhou Jingying; Liu Man; Sun Hanyong; Feng Yu; Xu Liangliang; Chan Anthony W. H.; Tong Joanna H.; Wong John; Chong Charing Ching Ning; Lai Paul B. S.; Wang Hector Kwong-Sang; Tsang Shun-Wa; Goodwin Tyler; Liu Rihe; Huang Leaf; Chen Zhiwei; Sung Joseph J. Y.; Chow King Lau; To Ka Fai; Cheng Alfred Sze-Lok;
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作者单位

Chinese Univ Hong Kong Sch Biomed Sci Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Sch Biomed Sci Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Med &

Therapeut Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Sch Biomed Sci Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Sch Biomed Sci Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Anat &

Cellular Pathol Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Anat &

Cellular Pathol Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Surg Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Surg Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Surg Hong Kong Hong Kong Peoples R China;

Hong Kong Univ Sci &

Technol Div Life Sci Hong Kong Hong Kong Peoples R China;

Hong Kong Univ Sci &

Technol Div Life Sci Hong Kong Hong Kong Peoples R China;

Univ North Carolina Chapel Hill Eshelman Sch Pharm Div Pharmacoengn &

Mol Pharmaceut Chapel Hill NC USA;

Univ North Carolina Chapel Hill Eshelman Sch Pharm Div Pharmacoengn &

Mol Pharmaceut Chapel Hill NC USA;

Univ North Carolina Chapel Hill Eshelman Sch Pharm Div Pharmacoengn &

Mol Pharmaceut Chapel Hill NC USA;

Univ Hong Kong AIDS Inst Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Med &

Therapeut Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Dept Anat &

Cellular Pathol Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Sch Biomed Sci Hong Kong Hong Kong Peoples R China;

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正文语种 eng
中图分类物理学;
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1. Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy [J] . Zhou Jingying, Liu Man, Sun Hanyong, Fortschritte der Physik . 2018,第5期

机译：肝癌内在CCRK抑制减少了骨髓衍生的抑制细胞免疫抑制，增强了免疫检查点阻滞效力
2. Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy [J] . Jingying Zhou, Man Liu, Hanyong Sun, Gut: Journal of the British Society of Gastroenterology . 2018,第5期

机译：肝癌内在CCRK抑制减少了骨髓衍生的抑制细胞免疫抑制，增强了免疫检查点阻滞效力
3. Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3K delta/gamma [J] . Davis Ruth J., Moore Ellen C., Clavijo Paul E., Cancer research: The official organ of the American Association for Cancer Research, Inc . 2017,第10期

机译：通过用PI3K Delta /γ的选择性抑制剂抑制髓样衍生的抑制细胞可以提高抗PD-L1功效
4. Sunitinib-Loaded Polymeric Nanoparticles to Deplete Myeloid-Derived Suppressor Cells and Enhance the #Efficacy of a Cancer Immunotherapy [C] . Cristina Maria de Barros, Sean Geary, Aliasger Salem Society for Biomaterials annual meeting and exposition . 2017

机译：装载舒尼替尼的聚合物纳米颗粒可耗尽骨髓来源的抑制细胞并增强癌症免疫疗法的功效。
5. Role of glioma-conditioned monocytes and myeloid-derived suppressor cells in glioma-mediated immunosuppression. [D] . Rodrigues, Jennifer Claire. 2008

机译：神经胶质瘤条件下的单核细胞和髓样来源的抑制细胞在神经胶质瘤介导的免疫抑制中的作用。
6. Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy [O] . Jingying Zhou, Man Liu, Hanyong Sun, -1

机译：肝癌固有CCRK抑制作用可减少髓样来源的抑制细胞的免疫抑制作用并增强免疫检查点的阻断功效
7. Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy [O] . Jingying Zhou, Man Liu, Hanyong Sun, 2017

机译：肝癌内在CCRK抑制减少了骨髓衍生的抑制细胞免疫抑制和增强免疫检查点延迟效能
8. Myeloid-Derived Suppressor Cells in Checkpoint Protein Inhibition for Melanoma. [R] . Weber, J. 2017

机译：骨髓来源的抑制细胞检测点蛋白抑制黑色素瘤。

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

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