Optimal vaccination and control strategies against dengue

摘要

This article focuses on the mathematical modelling of a disease outbreak of dengue fever. A cost-efficient fighting strategy, which simultaneously uses vaccination, application of insecticides to adult and aquatic mosquitoes, and an approach to decrease the number of man-made breeding places for the mosquitoes, is computed using optimal control. Vaccination includes a paediatric vaccination and an imperfect random mass vaccination with waning immunity.