Type-Itemized Enumeration of [2.2]Paracyclophane Derivatives for Recasting the Concept of Stereogenic Planes by Fujita's Stereoisogram Approach

摘要

Planar chirality of [2.2]Paracyclophane derivatives has been treated by applying Fujita's stereoisogram approach (Fujita, S. Mathematical Stereochemistry, De-Gruyter, 2015). By means of stereoisograms, three kinds of symmetries (chirality, RS-stereogenicity and sclerality) have been integrated into RS-stereoisomerism, which are classified into five types. Fujita's proligand method for 3D structure (Fujita, S. Symmetry and Combinatorial Enumeration in Chemistry, Springer-Verlag, 1991; Fujita, S. Combinatorial Enumeration of Graphs, Three-Dimensional Structures, and Chemical Compounds, University of Kragujevac, Faculty of Science: Kragujevac, 2013) has been extended to meet the requirement due to RS-stereoisomers and applied to the symmetry-itemized and type-itemized enumerations of [2.2]paracyclophane derivatives. The enumeration results are depicted by means of isomer-classification diagrams, which demonstrate isomerism of [2.2]paracyclophane derivatives.