Facile Photochemical Modification of Silk Protein–Based Biomaterials

Hardy John G.; Bertin Annabelle; Torres‐Rendon Jose Guillermo; Leal‐Ega?a Aldo; Humenik Martin; Bauer Felix; Walther Andreas; C?lfen Helmut; Schlaad Helmut; Scheibel Thomas R.

摘要

Abstract > Silk protein–based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein–based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk‐based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer‐modified silks are mineralized. The PAA‐ and PMAA‐functionalized silks are mineralized with calcium carbonate, whereas the PAAm‐functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >丝蛋白的材料显示应用作为组织工程的生物材料。报道了由 Bombyx Mori </ i>蚕丝或工程蜘蛛丝蛋白（EADF4（C16））组成的丝蛋白基材料的简单和快速的光化学修饰。在丝基材料上形成的自由基引发单体（丙烯酸，甲基丙烯酸或烯丙胺）的聚合，其用聚（丙烯酸）（PAA），聚（甲基丙烯酸）（PMAA）来官能化丝网表面的表面，或聚（allylamine）（Paam）。为了证明这种类型的改性的潜在应用，聚合物改性的丝网是矿化的。 PAA-和PMAA官能化丝网用碳酸钙矿化，而Paam官能化丝氨酸是用二氧化硅的矿化，两者都为骨组织工程有用的材料提供涂层，这将是未来的主题调查。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24307/'>《Macromolecular bioscience 》</a> <b style="margin: 0 2px;">|</b><span>2018年第11期</span><b style="margin: 0 2px;">|</b> <span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hardy John G.&option=202" target="_blank" rel="nofollow">Hardy John G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bertin Annabelle&option=202" target="_blank" rel="nofollow">Bertin Annabelle;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Torres‐Rendon Jose Guillermo&option=202" target="_blank" rel="nofollow">Torres‐Rendon Jose Guillermo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Leal‐Ega?a Aldo&option=202" target="_blank" rel="nofollow">Leal‐Ega?a Aldo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Humenik Martin&option=202" target="_blank" rel="nofollow">Humenik Martin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bauer Felix&option=202" target="_blank" rel="nofollow">Bauer Felix;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Walther Andreas&option=202" target="_blank" rel="nofollow">Walther Andreas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=C?lfen Helmut&option=202" target="_blank" rel="nofollow">C?lfen Helmut;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schlaad Helmut&option=202" target="_blank" rel="nofollow">Schlaad Helmut;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Scheibel Thomas R.&option=202" target="_blank" rel="nofollow">Scheibel Thomas R.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Biomaterials Faculty of Engineering Science University of BayreuthUniversit?tsstra?e 30 95447 Bayreuth Germany;</p> <p>German Federal Institute for Materials Research and Testing (BAM)Unter den Eichen 87 12205 Berlin Germany;</p> <p>DWI Leibniz Institute for Interactive MaterialsForckenbeckstra?e 50 52056 Aachen Germany;</p> <p>Biomaterials Faculty of Engineering Science University of BayreuthUniversit?tsstra?e 30 95447 Bayreuth Germany;</p> <p>Biomaterials Faculty of Engineering Science University of BayreuthUniversit?tsstra?e 30 95447 Bayreuth Germany;</p> <p>Biomaterials Faculty of Engineering Science University of BayreuthUniversit?tsstra?e 30 95447 Bayreuth Germany;</p> <p>DWI Leibniz Institute for Interactive MaterialsForckenbeckstra?e 50 52056 Aachen Germany;</p> <p>Physical Chemistry GroupDepartment of ChemistryUniversit?tsstra?e 10 78457 Konstanz Germany;</p> <p>Institute of ChemistryKarl‐Liebknecht‐Stra?e 24‐25 14476 Potsdam Germany;</p> <p>Biomaterials Faculty of Engineering Science University of BayreuthUniversit?tsstra?e 30 95447 Bayreuth Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物） ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biomaterials&option=203" rel="nofollow">biomaterials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=chemical modification&option=203" rel="nofollow">chemical modification;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=photochemistry&option=203" rel="nofollow">photochemistry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=silkworm silk&option=203" rel="nofollow">silkworm silk;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=spider silk&option=203" rel="nofollow">spider silk;</a> </p> <div class="translation"> 机译：生物材料;化学改性;光化学;蚕丝;蜘蛛丝; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li 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href="/conference-cn-11282/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中华中医药学会制剂分会、世界中联中药药剂专业委员会2011学术年会暨“龙津杯”中药制剂创新与发展论坛 </a> <span> <span> . 2011</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031634469.html">基于丝/苏氨酸位点-修饰网络的蛋白质翻译后修饰预测研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姜玉杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 姜玉杰</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120420748.html">光化学交联表面修饰生物材料的方法</a> <b>[P]</b> . <span> 中国专利： CN100431625C </span> <span> . 2008.11.12</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120105085660.html">光化学交联表面修饰生物材料的方法</a> <b>[P]</b> . <span> 中国专利： CN1887367A </span> <span> . 2007-01-03</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130453719179.html">elastic protein and elastic protein - based on the human body and the manufacturing method for the material, (ELASTIN, and ELASTIN - BASED BIOMATERIALS and PROCESS)</a> <b>[P]</b> . <span> 外国专利：  KR970706765A </span> <span> . 1997-12-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：弹性蛋白和弹性蛋白-基于人体和材料的制造方法（基于ELASTIN和ELASTIN的生物材料和过程） </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130409794390.html">Silk fibroin and polyethylene glycol-based biomaterials</a> <b>[P]</b> . <span> 外国专利：  US9566365B2 </span> <span> . 2017-02-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：丝素蛋白和聚乙二醇基生物材料 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130410494149.html">Biomaterials based on silk fibroin and polyethylene glycol</a> <b>[P]</b> . <span> 外国专利：  JP6081358B2 </span> <span> . 2017-02-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于丝素蛋白和聚乙二醇的生物材料 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023543281','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" 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