Implantable Nanotube Sensor Platform for Rapid Analyte Detection

Hofferber Eric Michael; Stapleton Joseph Anthony; Adams Janelle; Kuss Mitchell; Duan Bin; Iverson Nicole Marie

摘要

Abstract >The use of nanoparticles within living systems is a growing field, but the long‐term effects of introducing nanoparticles to a biological system are unknown. If nanoparticles remain localized after in vivo implantation unanticipated side effects due to unknown biodistribution can be avoided. Unfortunately, stabilization and retention of nanoparticles frequently alters their function.[1] In this work multiple hydrogel platforms are developed to look at long‐term localization of nanoparticle sensors with the goal of developing a sensor platform that will stabilize and localize the nanoparticles without altering their function. Two different hydrogel platforms are presented, one with a liquid core of sensors and another with sensors decorating the hydrogel's exterior, that are capable of localizing the nanoparticles without inhibiting their function. With the use of these new hydrogel platforms nanoparticle sensors can be easily implanted in vivo and utilized without concerns of nanoparticle impact on the animal. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >生活系统内的纳米颗粒的使用是一个日益增长的领域，但长期效果将纳米颗粒引入生物系统是未知的。如果纳米颗粒在体内植入后局部化，则可以避免由于未知生物分布而导致的未知副作用。遗憾的是，纳米颗粒的稳定和保留经常改变它们的功能。[1]在这项工作中，开发了多个水凝胶平台，以研究纳米粒子传感器的长期定位，目的是开发传感器平台，该平台将稳定和定位纳米颗粒而不改变其功能。提出了两个不同的水凝胶平台，一个具有传感器的液体核心，另一个具有装饰水凝胶的外部的传感器，能够定位纳米颗粒而不抑制其功能。通过使用这些新的水凝胶平台，纳米颗粒传感器可以容易地植入体内并使用纳米颗粒对动物的影响而使用。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24307/'>《Macromolecular bioscience》</a> <b style="margin: 0 2px;">|</b><span>2019年第6期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hofferber Eric Michael&option=202" target="_blank" rel="nofollow">Hofferber Eric Michael;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stapleton Joseph Anthony&option=202" target="_blank" rel="nofollow">Stapleton Joseph Anthony;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Adams Janelle&option=202" target="_blank" rel="nofollow">Adams Janelle;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kuss Mitchell&option=202" target="_blank" rel="nofollow">Kuss Mitchell;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Duan Bin&option=202" target="_blank" rel="nofollow">Duan Bin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Iverson Nicole Marie&option=202" target="_blank" rel="nofollow">Iverson Nicole Marie;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Biological Systems EngineeringUniversity of Nebraska‐Lincoln233 L. W. Chase Hall Lincoln NE 68583‐0726 USA;</p> <p>Department of Biological Systems EngineeringUniversity of Nebraska‐Lincoln233 L. W. Chase Hall Lincoln NE 68583‐0726 USA;</p> <p>Department of Biological Systems EngineeringUniversity of Nebraska‐Lincoln233 L. W. Chase Hall Lincoln NE 68583‐0726 USA;</p> <p>Regenerative Medicine ProgramUniversity of Nebraska Medical CenterDRC II 6035 UNMC Omaha NE 68198‐5965 USA;</p> <p>Regenerative Medicine ProgramUniversity of Nebraska Medical CenterDRC II 6035 UNMC Omaha NE 68198‐5965 USA;</p> <p>Department of Biological Systems EngineeringUniversity of Nebraska‐Lincoln233 L. W. Chase Hall Lincoln NE 68583‐0726 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biocompatibility&option=203" rel="nofollow">biocompatibility;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biomaterials&option=203" rel="nofollow">biomaterials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydrogels&option=203" rel="nofollow">hydrogels;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=molecular recognition&option=203" rel="nofollow">molecular recognition;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nanotechnology&option=203" rel="nofollow">nanotechnology;</a> </p> <div class="translation"> 机译：生物相容性;生物材料;水凝胶;分子识别;纳米技术; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div 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