Variation of intraindividual levels of endogenous GHB in segmented hair samples

摘要

Gamma-hydroxybutyrate (GHB) belongs to a group of substances that may be used in drug-facilitated crime (DFC). It is also an endogenous substance. There is a dispute whether or not a single exposure to GHB can be detected in hair. The first aim of this study was to develop and validate a method for the sensitive detection of base levels of GHB in hair. The second aim was to collect analytical data of 88 volunteers (62 females/26 males) not claiming any exposure to GHB and discuss the results in the context of the identification of a potential single exposure in cases of DFC. Furthermore hair samples from a male volunteer, who took GHB twice within 8 weeks, were analysed and the results were discussed with regard to mean values of endogenous GHB analysed in this study.