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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >Shape-engineered titanium dioxide nanoparticles (TiO2-NPs): cytotoxicity and genotoxicity in bronchial epithelial cells
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Shape-engineered titanium dioxide nanoparticles (TiO2-NPs): cytotoxicity and genotoxicity in bronchial epithelial cells

机译:形状工程化二氧化钛纳米粒子(TiO2-NPS):支气管上皮细胞中的细胞毒性和遗传毒性

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摘要

The aim of this study was to evaluate cytotoxicity (WST-1 assay), LDH release (LDH assay) and genotoxicity (Comet assay) of three engineered TiO2-NPs with different shapes (bipyramids, rods, platelets) in comparison with two commercial TiO2-NPs (P25, food grade). After NPs characterization (SEM/T-SEM and DLS), biological effects of NPs were assessed on BEAS-2B cells in presence/absence of light. The cellular uptake of NPs was analyzed using Raman spectroscopy.
机译:本研究的目的是评估三种工程化TiO2-NPS的细胞毒性(WST-1测定),LDH释放(LDH测定)和遗传毒性(彗星测定)与两种商业TiO2相比 -NPS(P25,食品等级)。 在NPS表征(SEM / T-SEM和DL)之后,在存在/不存在的BEA-2B细胞上评估NPS的生物学效应。 使用拉曼光谱分析NPS的细胞吸收。

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