An interference localized surface plasmon resonance biosensor based on the photonic structure of au nanoparticles and SiO_2/Si multilayers

摘要

This paper presents the experimental and simulation analysis of an original nanostructure design constructed with plasmonic gold nanoparticles and photonic thin-film multilayers of silicon dioxide (500 nm in thickness) and silicon on a substrate. Our nanostructure substrate showed a high sensitivity for various refractive index Rl solutions and a prominent capacity for functionalizing alkanethiol molecules on the gold surface and demonstrates great potential in the development of a microfluidic-based biosensor for monitoring biotin - avidin interactions in real-time.