Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophytic Aspergillus from Tripterygium wilfordii

摘要

Terrusnolides A?D (1–4), four butenolides were isolated from an endophytic Aspergillus from Tripterygium wilfordii. The structures of1–4were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculation. It is interesting that1was a butenolide derived by a triple decarboxylation, while2–4were the metabolites with 4-benzyl-3-phenyl-5H-furan-2-one motif possessing an isopentene group fused to the benzene ring.In vitroanti-inflammatory effects of these isolates were evaluated in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.1–4exhibited excellent inhibitory effects on the production of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and nitric oxide (NO) in LPS-induced macrophages, comparable with the positive control (indomethacin). Those results indicated that, terrusnolides A?D might serve as new potential natural remedies for the treatment of inflammation.