Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study.

摘要

OBJECTIVE: To compare the efficacy of oral dydrogesterone with that of micronized vaginal P gel and micronized P capsule for luteal supplementation. DESIGN: Prospective, randomized clinical study. SETTING: Institute of Reproductive Medicine, Kolkata, India. PATIENT(S): A total of 1,373 infertile women undergoing IVF participated. INTERVENTION(S): Micronized P gel, P capsule, and oral dydrogesterone were administered for luteal support and compared. MAIN OUTCOME MEASURE(S): Demographic profile and pregnancy and miscarriage rates. RESULT(S): The overall pregnancy rate and miscarriage rate were comparable among the three groups. CONCLUSION(S): Oral dydrogesterone seems to be a promising drug for luteal support in woman undergoing IVF.