Bovine viral diarrhoea virus infection alters uterine prostaglandin profiles and inhibits interferon tau initiated pregnancy recognition in cows

摘要

Poor reproductive performance, of which early embryonic mortality is a major component, causes significant economic loss to the dairy industry. Embryonic mortality rates in cattle can be as high as 40%, with 70-80% of losses occurring before day 16 ofgestation (Diskin et al. 2011). Evidence has shown that early embryonic mortality in cows can be caused by failed PR and BVDV infection (Grooms 2014). Prostaglandins (PG) play important roles in many reproductive processes, including luteolysis, pregnancy recognition and implantation. The aims of the present study were to investigate the effect of BVDV infection on uterine PG production and PR using an in vitro endometrial PR model.