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The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex

机译：电压门控钙通道Cav1.2促进小鼠胼callosum中的成人少突胶质细胞祖细胞存活，但不是电机皮质

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Abstract > Throughout life, oligodendrocyte progenitor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes. OPCs express cell surface receptors and channels that allow them to detect and respond to neuronal activity, including voltage‐gated calcium channel (VGCC)s. The major L‐type VGCC expressed by developmental OPCs, CaV1.2, regulates their differentiation. However, it is unclear whether CaV1.2 similarly influences OPC behavior in the healthy adult central nervous system (CNS). To examine the role of CaV1.2 in adulthood, we conditionally deleted this channel from OPCs by administering tamoxifen to P60 Cacna1c fl / fl (control) and Pdgfrα‐CreER :: Cacna1c fl / fl (CaV1.2‐deleted) mice. Whole cell patch clamp analysis revealed that CaV1.2 deletion reduced L‐type voltage‐gated calcium entry into adult OPCs by ~60%, confirming that it remains the major L‐type VGCC expressed by OPCs in adulthood. The conditional deletion of CaV1.2 from adult OPCs significantly increased their proliferation but did not affect the number of new oligodendrocytes produced or influence the length or number of internodes they elaborated. Unexpectedly, CaV1.2 deletion resulted in the dramatic loss of OPCs from the corpus callosum, such that 7?days after tamoxifen administration CaV1.2‐deleted mice had an OPC density ~42% that of control mice. OPC density recovered within 2?weeks of CaV1.2 deletion, as the lost OPCs were replaced by surviving CaV1.2‐deleted OPCs. As OPC density was not affected in the motor cortex or spinal cord, we conclude that calcium entry through CaV1.2 is a critical survival signal for a subpopulation of callosal OPCs but not for all OPCs in the mature CNS. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 在整个寿命期间，少突胶质细胞祖细胞（OPCs）增殖并分化为髓鞘寡核细胞。 OPCS表达细胞表面受体和通道，其允许它们检测和响应神经元活动，包括电压门控钙通道（VGCC）S。由发育OPCS，CAV1.2表示的主要L型VGCC调节其差异化。然而，目前尚不清楚CAV1.2是否类似地影响健康成人中枢神经系统（CNS）中的OPC行为。为了检查Cav1.2在成年中的作用，我们通过将Tamoxifen施用到P60，有条件地从OPCS中删除了该通道 cacna1c </ i> fl </ i> / fl </ i> </ sup> （控制）和 pdgfrα-reer </ i> :: cacna1c </ i> fl </ i> / fl </ i> </ sup> （Cav1.2删除）小鼠。全细胞膜片钳分析显示，CAV1.2删除将L型电压门控钙入口减少到成人OPCS〜60％，确认它仍然是APCS在成年期表达的主要L型VGCC。来自成年OPCs的Cav1.2的条件缺失显着提高了它们的增殖，但不影响产生的新的少寡核细胞的数量或影响它们所阐述的间度的长度或数量。出乎意料的是，CAV1.2缺失导致来自语料癌的OPCs的显着丧失，使得Tamoxifen施用Cav1.2缺失的小鼠的7.℃，具有对照小鼠的OPC密度〜42％。由于丢失的OPCS被存活的Cav1.2删除的OPCs取代，OPC密度在2个缺失内恢复。由于OPC密度在电动机皮层或脊髓中不受影响，我们得出结论，通过CAV1.2的钙入口是用于调用OPC的群体但不适用于成熟CNS中的所有OPCS的关键生存信号。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-23771/'>《Glia》</a> <b style="margin: 0 2px;">|</b><span>2020年第2期</span><b style="margin: 0 2px;">|</b><span>共17页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pitman Kimberley A.&option=202" target="_blank" rel="nofollow">Pitman Kimberley A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ricci Raphael&option=202" target="_blank" rel="nofollow">Ricci Raphael;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gasperini Robert&option=202" target="_blank" rel="nofollow">Gasperini Robert;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Beasley Shannon&option=202" target="_blank" rel="nofollow">Beasley Shannon;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pavez Macarena&option=202" target="_blank" rel="nofollow">Pavez Macarena;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Charlesworth Jac&option=202" target="_blank" rel="nofollow">Charlesworth Jac;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Foa Lisa&option=202" target="_blank" rel="nofollow">Foa Lisa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Young Kaylene M.&option=202" target="_blank" rel="nofollow">Young Kaylene M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Menzies Institute for Medical ResearchUniversity of TasmaniaHobart Australia;</p> <p>Menzies Institute for Medical ResearchUniversity of TasmaniaHobart Australia;</p> <p>Menzies Institute for Medical ResearchUniversity of TasmaniaHobart Australia;</p> <p>Menzies Institute for Medical ResearchUniversity of TasmaniaHobart Australia;</p> <p>Menzies Institute for Medical ResearchUniversity of TasmaniaHobart Australia;</p> <p>Menzies Institute for Medical ResearchUniversity of TasmaniaHobart Australia;</p> <p>School of MedicineUniversity of TasmaniaHobart Australia;</p> <p>Menzies Institute for Medical ResearchUniversity of TasmaniaHobart Australia;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=apoptosis&option=203" rel="nofollow">apoptosis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cacna1C&option=203" rel="nofollow">Cacna1C;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=calcium&option=203" rel="nofollow">calcium;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CaV1.2&option=203" rel="nofollow">CaV1.2;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=corpus callosum&option=203" rel="nofollow">corpus callosum;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=motor cortex&option=203" rel="nofollow">motor cortex;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=NG2&option=203" rel="nofollow">NG2;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oligodendrocyte&option=203" rel="nofollow">oligodendrocyte;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=proliferation&option=203" rel="nofollow">proliferation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=survival&option=203" rel="nofollow">survival;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=voltage‐gated calcium channel&option=203" rel="nofollow">voltage‐gated calcium channel;</a> </p> <div class="translation"> 机译：细胞凋亡;cacna1c;钙;cav1.2;胼callosum;motor cortex;ng2;oligodendrocyte;增殖;生存;存活;电压门控钙通道; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023429867.html">The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex</a> <b>[J]</b> . <span> <a 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Hamilton&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">N. B. Hamilton,</a> <span>2012</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：小鼠胼call病变，电动机皮层和小鼠吡虫粒皮层中少突胚细胞祖细胞的性质和命运</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_neural-injury-functional-reconstruction_thesis/0201275227365.html">电压门控钙离子通道CaV1.2促进小鼠胼胝体而非运动皮质中成年少突胶质祖细胞的存活</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pitman KA&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Pitman KA</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ricci R&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Ricci R</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gasperini R&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Gasperini R</a> <span> <a href="/journal-cn-6239/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 神经损伤与功能重建 </a> </span> <span> . 2019</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-pharmacology-toxicology_thesis/0201242267026.html">皮质酮对大鼠海马神经元电压门控性钙通道及其突触活动的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郑建全&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 郑建全</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨爱珍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨爱珍</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周建政&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,周建政</a> <span> <a href="/journal-cn-6428/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国药理学与毒理学杂志 </a> </span> <span> . 2002</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-international-journal-medicine_thesis/0201257016478.html">皮质酮快速抑制效应的电压门控钙通道机制</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=娄淑杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 娄淑杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈宜张&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈宜张</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=路长林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,路长林</a> <span> <a href="/journal-cn-6773/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中华国际医学杂志 </a> </span> <span> . 2001</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-conservative-dentistry_thesis/0201238734748.html">早衰小鼠骨髓间充质干细胞电压门控钙通道的表达检测</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张辉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘窕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘窕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李蓓&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李蓓</a> <span> <a href="/journal-cn-6319/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 牙体牙髓牙周病学杂志 </a> </span> <span> . 2016</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-brain-nervous-diseases_thesis/0201237336963.html">电压门控钙通道在癫痫中的作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈建行&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈建行</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张帆&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张帆</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=贾瑞梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,贾瑞梅</a> <span> <a href="/journal-cn-6247/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 脑与神经疾病杂志 </a> </span> <span> . 2017</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-1673_thesis/02022253406.html">Spexin通过甘丙肽受体2介导的L-型电压门控钙通道促进肠道运动</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=林成源&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 林成源</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=卞兆祥&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,卞兆祥</a> <span> <a href="/conference-cn-1673/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界中医药学会联合会消化病专业委员会第六届消化病国际学术大会 </a> <span> <span> . 2015</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315230131.html">电压门控钙通道亚基Cacnb3调控小鼠脂肪间充质干细胞成骨分化的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=伏玺&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 伏玺</a> <span> . 2019</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130404241906.html">CULTURE, DEVICE, AND COMPOSITION FOR PRODUCING ADULT OLIGODENDROCYTE-TYPE 2 ASTROCYTE PROGENITOR CELLS AND PROLIFERATING OLIGODENDROCYTE-TYPE 2 ASTROCYTE PROGENITOR CELLS</a> <b>[P]</b> . <span> 外国专利：  US2019117704A1 </span> <span> . 2019-04-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：培养成人寡糖2型星形胶质细胞祖细胞和增殖寡糖2型星形胶质细胞祖细胞的文化，设备和组合物 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130415192641.html">purified complex; recombinant host cell; method for identifying a test compound that enhances the formation of a complex including the test compound; method of enhancing the formation of a complex including an immunophilin binder; method of decreasing membrane tension-dependent opening of the calcium channel activity, and / or fkbp52 activity, in a cell; method of stimulating neurite growth and / or survival of a neuronal cell; method of treating a disorder associated with type 1 calcium channel dysfunction; method of stimulating neurite growth of a neuronal cell; use of an immunophilin binder; use of an immunophilin binder in combination with a type 1 calcium channel antagonist; immunophilin binder; and composition.</a> <b>[P]</b> . <span> 外国专利：  BRPI0721236A2 </span> <span> . 2015-09-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：纯化的复合物;重组宿主细胞鉴定增强包括该测试化合物的复合物形成的测试化合物的方法;增强包括亲免蛋白结合物的复合物形成的方法;减少细胞中依赖于膜张力的钙通道活性和/或fkbp52活性的打开的方法;刺激神经突生长和/或神经细胞存活的方法;治疗与1型钙通道功能障碍有关的疾病的方法;刺激神经元神经突生长的方法;亲免蛋白粘合剂的用途;亲免蛋白结合剂与1型钙通道拮抗剂联合使用;亲免蛋白粘合剂和组成。 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130402080923.html">Method for producing adult oligodendrocyte progenitor cells</a> <b>[P]</b> . <span> 外国专利：  JP6615616B2 </span> <span> . 2019-12-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：成年少突胶质祖细胞的生产方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023429867','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img 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