Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na        <sup >++        /K        <sup >++        ATPase

Tapella Laura; Soda Teresa; Mapelli Lisa; Bortolotto Valeria; Bondi Heather; Ruffinatti Federico A.; Dematteis Giulia; Stevano Alessio; Dionisi Marianna; Ummarino Simone; Di Ruscio Annalisa; Distasi Carla; Grilli Mariagrazia; Genazzani Armando A.; DAngelo Egidio; Moccia Francesco; Lim Dmitry

摘要

Abstract > Astrocytes perform important housekeeping functions in the nervous system including maintenance of adequate neuronal excitability, although the regulatory mechanisms are currently poorly understood. The astrocytic Ca 2+ /calmodulin‐activated phosphatase calcineurin (CaN) is implicated in the development of reactive gliosis and neuroinflammation, but its roles, including the control of neuronal excitability, in healthy brain is unknown. We have generated a mouse line with conditional knockout (KO) of CaN B1 (CaNB1) in glial fibrillary acidic protein‐expressing astrocytes ( cssStyle="text-decoration:underline">a stroglial cssStyle="text-decoration:underline">c alci cssStyle="text-decoration:underline">n eurin cssStyle="text-decoration:underline">KO [ACN‐KO]). Here, we report that postnatal and astrocyte‐specific ablation of CaNB1 did not alter normal growth and development as well as adult neurogenesis. Yet, we found that specific deletion of astrocytic CaN selectively impairs intrinsic neuronal excitability in hippocampal CA1 pyramidal neurons and cerebellar granule cells (CGCs). This impairment was associated with a decrease in after hyperpolarization in CGC, while passive properties were unchanged, suggesting impairment of K + homeostasis. Indeed, blockade of Na + /K + ‐ATPase (NKA) with ouabain phenocopied the electrophysiological alterations observed in ACN‐KO CGCs. In addition, NKA activity was significantly lower in cerebellar and hippocampal lysates and in pure astrocytic cultures from ACN‐KO mice. While no changes were found in protein levels, NKA activity was inhibited by the specific CaN inhibitor FK506 in both cerebellar lysates and primary astroglia from control mice, suggesting that CaN directly modulates NKA activity and in this manner controls neuronal excitability. In summary, our data provide formal evidence for the notion that astroglia is fundamental for controlling basic neuronal functions and place CaN center‐stage as an astrocytic Ca 2+ ‐sensitive switch. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 星形胶质细胞在神经系统中执行重要的内政功能，包括维持足够的神经元兴奋性，尽管该监管机制目前尚未理解。星形胶合剂 2 + </ sup> /钙调蛋白激活的磷酸酶钙素素（CAN）涉及活性脊髓源性和神经炎炎症的发育，但其作用，包括控制神经元兴奋性，在健康的大脑中未知。我们在胶质纤维酸性蛋白质 - 表达星形细胞中产生了CAN B1（Canb1）的条件淘汰（ko）的鼠标线（ cssstyle =“text-decoration：下划线”> a </ span> str cssstyle =“text-decoration：下划线”> c </ span> alci. cssstyle =“text-decoration：下划线”> n </ span> 欧洲 cssstyle =“文本装饰：下划线”> KO </ SPAN> [acn-ko]）。在这里，我们报告的是，产后和星形胶质细胞特异性消融CanB1没有改变正常的生长和发展以及成年神经发生。然而，我们发现星形胶质细胞的特异性缺失可以在海马CA1金字塔神经元和小脑颗粒细胞（CGCs）中选择性地损害内在神经元兴奋性。这种损伤与CGC中超极化后的减少有关，而被动性质不变，表明K的损害 + </ sup> 稳态。的确，封锁了na + </ sup> / K. + </ sup> - 蛋白酶（NKA）与Ouabain，在ACN-KO CGCs中观察到的电生理改变。此外，小脑和海马裂解物的NKA活性显着降低，来自ACN-KO小鼠的纯星形织造型。虽然在蛋白质水平中没有发现任何变化，但是在对照小鼠中，特定的CAN抑制剂FK506抑制了NKA活性，这表明可以直接调节NKA活性，并以这种方式控制神经元兴奋性。总之，我们的数据提供了表演的正式证据，以至于Astroglia对控制基本神经元功能的基础，并将其作为星形胶质型CA的职位 2 + </ sup> - 敏感开关。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-23771/'>《Glia》</a> <b style="margin: 0 2px;">|</b><span>2020年第3期</span><b style="margin: 0 2px;">|</b><span>共18页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tapella Laura&option=202" target="_blank" rel="nofollow">Tapella Laura;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Soda Teresa&option=202" target="_blank" rel="nofollow">Soda Teresa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mapelli Lisa&option=202" target="_blank" rel="nofollow">Mapelli Lisa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bortolotto Valeria&option=202" target="_blank" rel="nofollow">Bortolotto Valeria;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bondi Heather&option=202" target="_blank" rel="nofollow">Bondi Heather;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ruffinatti Federico A.&option=202" target="_blank" rel="nofollow">Ruffinatti Federico A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dematteis Giulia&option=202" target="_blank" rel="nofollow">Dematteis Giulia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stevano Alessio&option=202" target="_blank" rel="nofollow">Stevano Alessio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dionisi Marianna&option=202" target="_blank" rel="nofollow">Dionisi Marianna;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ummarino Simone&option=202" target="_blank" rel="nofollow">Ummarino Simone;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Di Ruscio Annalisa&option=202" target="_blank" rel="nofollow">Di Ruscio Annalisa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Distasi Carla&option=202" target="_blank" rel="nofollow">Distasi Carla;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Grilli Mariagrazia&option=202" target="_blank" rel="nofollow">Grilli Mariagrazia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Genazzani Armando A.&option=202" target="_blank" rel="nofollow">Genazzani Armando A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DAngelo Egidio&option=202" target="_blank" rel="nofollow">DAngelo Egidio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Moccia Francesco&option=202" target="_blank" rel="nofollow">Moccia Francesco;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lim Dmitry&option=202" target="_blank" rel="nofollow">Lim Dmitry;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Brain and Behavioral SciencesUniversity of PaviaPavia Italy;</p> <p>Department of Brain and Behavioral SciencesUniversity of PaviaPavia Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Center of Life ScienceMedical School Initiative for RNA Medicine Harvard Medical SchoolBoston Massachusetts;</p> <p>Center of Life ScienceMedical School Initiative for RNA Medicine Harvard Medical SchoolBoston Massachusetts;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> <p>Department of Brain and Behavioral SciencesUniversity of PaviaPavia Italy;</p> <p>Department of Biology and Biotechnology “Lazzaro Spallanzani”University of PaviaPavia Italy;</p> <p>Department of Pharmaceutical SciencesUniversità del Piemonte Orientale “Amedeo Avogadro”Novara Italy;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 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</div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：从GFAP表达的星形胶质细胞中删除钙调解素损害小脑和海马神经元的兴奋性通过星形族NA + </ sup> + / K. + </ sup> + ATPase.</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022656368.html">Deletion of calcineurin from GFAP-expressing astrocytes impairs neuronal excitability and reproduces features of neurological diseases.</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> </a> <a href="/journal-foreign-19203/" target="_blank" rel="nofollow" class="tuijian_authcolor">Acta physiologica .</a> <span>2019</span><span>,第S722期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: 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Jalonen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tuula O. Jalonen </a> <a href="/conference-foreign-268592/" target="_blank" rel="nofollow" class="tuijian_authcolor">Computational Neuroscience Meeting .</a> <span>2004</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：集小脑颗粒神经元兴奋性和钙信号通路的模型</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061460868.html">Glucocorticoids regulate the expression of NGF, bFGF, and S100-beta in cultured hippocampal astrocytes: Impact on hippocampal neuron survival.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Niu, Helen Hairong.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Niu, Helen Hairong. </a> <span>1996</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: 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<span>1997</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：反义神经胶质纤维酸性蛋白（GFAP）mRNA诱导的神经元-星形胶质细胞共培养物中神经胶质细胞增生与星形胶质细胞表型变化有关。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000127289397.html">Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+/K+ATPase</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Laura Tapella&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Laura Tapella,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Teresa Soda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Teresa Soda,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lisa Mapelli&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lisa Mapelli,</a> <span>2019</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：从GFAP表达的星形胶质细胞缺失钙调毒素通过星形族Na + / K + ATP酶损害小脑和海马神经元的兴奋性</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-tissue-engineering-research_thesis/0201252510382.html">海马活化素βA亚基基因表达与神经元对抗兴奋性损害内源性保护效应的关系</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=余巨明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 余巨明</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨德本&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨德本</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=任惠民&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,任惠民</a> <span> <a href="/journal-cn-15352/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织工程研究 </a> </span> <span> . 2005</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-kunming-medical-university_thesis/0201245020906.html">糖尿病小鼠海马星形胶质细胞GFAP表达的变化</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨力&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杨力</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵培园&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵培园</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=战雅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,战雅</a> <span> <a href="/journal-cn-6509/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 昆明医科大学学报 </a> </span> <span> . 2010</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-guangxi-medical-university_thesis/0201244077756.html">酒精中毒对小鼠海马星形胶质细胞表达GFAP及学习记忆的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=檀松&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 檀松</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董艳玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,董艳玲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=梁浩&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,梁浩</a> <span> <a href="/journal-cn-6487/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 广西医科大学学报 </a> </span> <span> . 2009</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_basic-clinical-medicine_thesis/0201222725393.html">卡马西平对大鼠海马星形胶质细胞形态和GFAP表达的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李杏色&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李杏色</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=柴锡庆&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,柴锡庆</a> <span> <a href="/journal-cn-5759/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 基础医学与临床 </a> </span> <span> . 2006</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-histochemistry-cytochemistry_thesis/0201255630034.html">正加速度暴露对大鼠海马星形胶质细胞GFAP表达的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐冶&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 徐冶</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李质馨&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李质馨</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=田洪艳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,田洪艳</a> <span> <a href="/journal-cn-5127/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织化学与细胞化学杂志 </a> </span> <span> . 2005</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313461583.html">砷暴露对小鼠海马星形胶质细胞GFAP和S-100β表达及神经元尼氏小体的影响</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙迪&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 孙迪</a> <span> . 2010</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130432592429.html">Distinguishing between rat neurons and rat astrocytes comprises assaying a body fluid or tissue sample containing brain cells to detect specific neuron- or astrocyte-expressed proteins</a> <b>[P]</b> . <span> 外国专利：  AT501960B1 </span> <span> . 2008-03-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：区分大鼠神经元和大鼠星形胶质细胞包括分析含有脑细胞的体液或组织样品，以检测特定的神经元或星形胶质细胞表达蛋白 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130427543139.html">NOVEL PEPTIDE FOR AUGMENTING BRAIN-DERIVED NEUTROTROPHIC FACTOR (BDNF) PROTEIN EXPRESSION IN HIPPOCAMPAL NEURONS, HIPPOCAMPAL TISSUE AND CEREBRAL-CORTEX TISSUE</a> <b>[P]</b> . <span> 外国专利：  WO2009136752A3 </span> <span> . 2010-03-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新型肽可增强海马神经元，海马组织和脑皮质组织中脑源性中性养分因子（BDNF）蛋白的表达 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130427543138.html">NOVEL PEPTIDE FOR AUGMENTING BRAIN-DERIVED NEUTROTROPHIC FACTOR (BDNF) PROTEIN EXPRESSION IN HIPPOCAMPAL NEURONS, HIPPOCAMPAL TISSUE AND CEREBRAL-CORTEX TISSUE</a> <b>[P]</b> . <span> 外国专利：  WO2009136752A9 </span> <span> . 2010-01-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新型肽可增强海马神经元，海马组织和脑皮质组织中脑源性中性养分因子（BDNF）蛋白的表达 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" 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Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na ++ /K ++ ATPase

摘要

Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na ^{++ /K ^{++ ATPase}}