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Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells

机译：人类IPSC衍生的小胶质细胞：一种越来越多的工具集，用于研究大脑的先天免疫细胞

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Abstract >Recent advances in the generation of microglia from human induced pluripotent stem cells (iPSCs) have provided exciting new approaches to examine and decipher the biology of microglia. As these techniques continue to evolve to encompass more complex in situ and in vivo paradigms, so too have they begun to yield novel scientific insight into the genetics and function of human microglia. As such, researchers now have access to a toolset comprised of three unique “flavors” of iPSC‐derived microglia: in vitro microglia (iMGs), organoid microglia (oMGs), and xenotransplanted microglia (xMGs). The goal of this review is to discuss the variety of research applications that each of these techniques enables and to highlight recent discoveries that these methods have begun to uncover. By presenting the research paradigms in which each model has been successful, as well as the key benefits and limitations of each approach, it is our hope that this review will help interested researchers to incorporate these techniques into their studies, collectively advancing our understanding of human microglia biology. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >从人诱导的多能干细胞（IPSC）产生微胶质细胞的最新进展，提供了令人兴奋的新方法来检查和破译微胶质细胞的生物学。由于这些技术仍然发展来涵盖原位和体内范式的更复杂，因此他们也开始产生新的科学洞察人类小叶草的遗传和功能。因此，研究人员现在可以访问由IPSC衍生的微胶质细胞的三种独特的“味道”组成的工具集：体外小胶质细胞（IMG），有机体小胶质细胞（OMG）和异种持久的微胶质细胞（XMG）。本次审查的目标是讨论各种研究应用程序，即每个技术都可以启用，并突出这些方法已经开始揭示的最新发现。通过介绍每个模型成功的研究范式，以及每种方法的关键益处和局限性，我们希望本综述将有利于研究人员将这些技术纳入他们的研究，共同推进我们对人类的理解microglia生物学。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-23771/'>《Glia》</a> <b style="margin: 0 2px;">|</b><span>2020年第4期</span><b style="margin: 0 2px;">|</b><span>共19页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hasselmann Jonathan&option=202" target="_blank" rel="nofollow">Hasselmann Jonathan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Blurton‐Jones Mathew&option=202" target="_blank" rel="nofollow">Blurton‐Jones Mathew;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Neurobiology and BehaviorUniversity of California IrvineIrvine California;</p> <p>Department of Neurobiology and BehaviorUniversity of California IrvineIrvine California;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cerebral organoids&option=203" rel="nofollow">cerebral organoids;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=chimeric&option=203" rel="nofollow">chimeric;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=induced pluripotent stem cells&option=203" rel="nofollow">induced pluripotent stem cells;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microglia&option=203" rel="nofollow">microglia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microglia‐like cells&option=203" rel="nofollow">microglia‐like cells;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=xenotransplantation&option=203" rel="nofollow">xenotransplantation;</a> </p> <div class="translation"> 机译：脑有机体;嵌合;诱导多能干细胞;小胶质细胞;微胶质细胞状细胞;异种传道; </div> </li> <li> <span class="lefttit">入库时间</span> <span>2022-08-20 03:19:41</span> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023429797.html">Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hasselmann Jonathan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hasselmann Jonathan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Blurton‐Jones Mathew&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Blurton‐Jones Mathew </a> <a href="/journal-foreign-23771/" target="_blank" rel="nofollow" class="tuijian_authcolor">Glia .</a> <span>2020</span><span>,第4期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人类IPSC衍生的小胶质细胞：一种越来越多的工具集，用于研究大脑的先天免疫细胞</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023877809.html">iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Abud Edsel M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Abud Edsel M.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ramirez Ricardo N.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ramirez Ricardo N.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Martinez Eric S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Martinez Eric S.,</a> <a href="/journal-foreign-25817/" target="_blank" rel="nofollow" class="tuijian_authcolor">Neuron .</a> <span>2017</span><span>,第2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：IPSC衍生的人类小胶质细胞样细胞研究神经疾病</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204121936142.html">Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ranjie Xu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ranjie Xu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiaoxi Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xiaoxi Li,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Andrew J. 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