MicroRNA‐365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting        <i xmlns='http://www.wiley.com/namespaces/wiley'>Pax6Pax6

Mo Jia‐Lin; Liu Qi; Kou Zeng‐Wei; Wu Kun‐Wei; Yang Ping; Chen Xian‐Hua; Sun Feng‐Yan

摘要

Abstract > Reactive astrocytes induced by ischemia can transdifferentiate into mature neurons. This neurogenic potential of astrocytes may have therapeutic value for brain injury. Epigenetic modifications are widely known to involve in developmental and adult neurogenesis. PAX6, a neurogenic fate determinant, contributes to the astrocyte‐to‐neuron conversion. However, it is unclear whether microRNAs (miRs) modulate PAX6‐mediated astrocyte‐to‐neuron conversion. In the present study we used bioinformatic approaches to predict miRs potentially targeting Pax6 , and transient middle cerebral artery occlusion (MCAO) to model cerebral ischemic injury in adult rats. These rats were given striatal injection of glial fibrillary acidic protein targeted enhanced green fluorescence protein lentiviral vectors (Lv‐GFAP‐EGFP) to permit cell fate mapping for tracing astrocytes‐derived neurons. We verified that miR‐365 directly targets to the 3′‐UTR of Pax6 by luciferase assay. We found that miR‐365 expression was significantly increased in the ischemic brain. Intraventricular injection of miR‐365 antagomir effectively increased astrocytic PAX6 expression and the number of new mature neurons derived from astrocytes in the ischemic striatum, and reduced neurological deficits as well as cerebral infarct volume. Conversely, miR‐365 agomir reduced PAX6 expression and neurogenesis, and worsened brain injury. Moreover, exogenous overexpression of PAX6 enhanced the astrocyte‐to‐neuron conversion and abolished the effects of miR‐365. Our results demonstrate that increase of miR‐365 in the ischemic brain inhibits astrocyte‐to‐neuron conversion by targeting Pax6 , whereas knockdown of miR‐365 enhances PAX6‐mediated neurogenesis from astrocytes and attenuates neuronal injury in th </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> >缺血诱导的无功星形胶质可以转化为成熟神经元。星形胶质细胞的这种神经源性潜力可能具有脑损伤的治疗价值。众所周知，表观遗传修饰涉及发育和成人神经发生。 PAX6，神经源性命运决定簇有助于星形胶质细胞至神经元转化。然而，目前尚不清楚microRNAs（mirs）调节pax6介导的星形胶质细胞 - 神经元转化。在本研究中，我们使用生物信息化方法来预测潜在地靶向 pax6的miR，以及瞬时中脑动脉闭塞（MCAO），以模拟成年大鼠的脑缺血性损伤。将这些大鼠施用纤维素注射胶质纤维酸性蛋白靶向增强的绿色荧光蛋白慢病毒载体（LV-GFAP-EGFP），以允许用于追踪星形胶质细胞衍生神经元的细胞命运映射。我们通过Luciferase测定验证了miR-365直接靶向 pax6 </ i>的3'-UTR。我们发现缺血性大脑中miR-365表达明显增加。脑内注射miR-365 intagomir有效地增加了星形胶质细胞pax6表达和缺血性纹状体中星形胶质细胞的新成熟神经元的数量，以及降低神经缺陷以及脑梗塞体积。相反，MiR-365 Agomir减少了PAX6表达和神经发生，脑损伤恶化。此外，PAX6的外源性过表达增强了星形胶质细胞与神经元转化，并废除了miR-365的影响。我们的结果表明，缺血性脑中miR-365的增加通过靶向来靶向半胶质细胞至神经元转化，而miR-365的敲低增强了从星形胶质细胞的pax6介导的神经发生，并衰减神经元损伤 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-23771/'>《Glia》</a> <b style="margin: 0 2px;">|</b><span>2018年第7期</span><b style="margin: 0 2px;">|</b><span>共17页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mo Jia‐Lin&option=202" target="_blank" rel="nofollow">Mo Jia‐Lin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Qi&option=202" target="_blank" rel="nofollow">Liu Qi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kou Zeng‐Wei&option=202" target="_blank" rel="nofollow">Kou Zeng‐Wei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Kun‐Wei&option=202" target="_blank" rel="nofollow">Wu Kun‐Wei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Ping&option=202" target="_blank" rel="nofollow">Yang Ping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Xian‐Hua&option=202" target="_blank" rel="nofollow">Chen Xian‐Hua;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sun Feng‐Yan&option=202" target="_blank" rel="nofollow">Sun Feng‐Yan;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Neurobiology and State Key Laboratory of Medical Neurobiology School of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032 China;</p> <p>Department of Neurobiology and State Key Laboratory of Medical Neurobiology School of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032 China;</p> <p>Department of Neurobiology and State Key Laboratory of Medical Neurobiology School of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032 China;</p> <p>Department of Neurobiology and State Key Laboratory of Medical Neurobiology School of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032 China;</p> <p>Department of Neurobiology and State Key Laboratory of Medical Neurobiology School of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032 China;</p> <p>Department of Neurobiology and State Key Laboratory of Medical Neurobiology School of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032 China;</p> <p>Department of Neurobiology and State Key Laboratory of Medical Neurobiology School of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=astrocyte&option=203" rel="nofollow">astrocyte;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=brain repair&option=203" rel="nofollow">brain repair;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=glia&option=203" rel="nofollow">glia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ischemic injury&option=203" rel="nofollow">ischemic injury;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microRNA&option=203" rel="nofollow">microRNA;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neurogenesis&option=203" rel="nofollow">neurogenesis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neuron&option=203" rel="nofollow">neuron;</a> </p> <div class="translation"> 机译：星形胶质细胞;脑修复;Glia;缺血性损伤;microRNA;神经发生;神经元; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023429685.html">MicroRNA‐365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting <i xmlns="http://www.wiley.com/namespaces/wiley">Pax6Pax6</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mo Jia‐Lin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mo Jia‐Lin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Qi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liu Qi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kou Zeng‐Wei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kou Zeng‐Wei,</a> <a href="/journal-foreign-23771/" target="_blank" rel="nofollow" class="tuijian_authcolor">Glia .</a> <span>2018</span><span>,第7期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：MicroRNA-365通过靶向<i XMLNS =“http://www.wiley.com/namespaces/wiley”> pax6 </ i> pax6</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023664897.html">Alteration of <fc xmlns="http://www.wiley.com/namespaces/wiley">CAI</fc>CAI s as recorded by <sup xmlns="http://www.wiley.com/namespaces/wiley">3636 S/ <sup xmlns="http://www.wiley.com/namespaces/wiley">3434 S as a function of <sup xmlns="http://www.wiley.com/namespaces/wiley">3535 Cl/ <sup xmlns="http://www.wiley.com/namespaces/wiley">3434 S</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Leya I.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Leya I.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Masarik J.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Masarik J.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lin Y.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lin Y. </a> <a href="/journal-foreign-24922/" target="_blank" rel="nofollow" class="tuijian_authcolor">Meteoritics & planetary science .</a> <span>2018</span><span>,第6期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：改变 <fc xmlns =“http://www.wiley.com/namespaces/wiley”> cai </ fc> cai s录制的 <sup xmlns =“http://www.wiley.com/namespaces/wiley”> 36 </ sup> 36 S / <sup xmlns =“http://www.wiley.com/namespaces/wiley”> 34 </ sup> 34 s作为一个函数 <sup xmlns =“http://www.wiley.com/namespaces/wiley”> 35 </ sup> 35 CL / <sup xmlns =“http://www.wiley.com/namespaces/wiley”> 34 </ sup> 34 S.</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025814989.html">Raman study of HoFe <sub xmlns="http://www.wiley.com/namespaces/wiley">3</sub>3 (BO <sub xmlns="http://www.wiley.com/namespaces/wiley">3</sub>3 ) <sub xmlns="http://www.wiley.com/namespaces/wiley">4</sub>4 at simultaneously high pressure and high temperature: <i xmlns="http://www.wiley.com/namespaces/wiley">pp – <i xmlns="http://www.wiley.com/namespaces/wiley">TT phase diagram</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krylov A. S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Krylov A. S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gudim I. A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gudim I. A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nemtsev I.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nemtsev I.,</a> <a href="/journal-foreign-35645/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Raman Spectroscopy: An International Journal for Original Work in All Aspects of Raman Spectroscopy, Including Higher Order Processes, and Also Brillouin- and Rayleigh Scattering .</a> <span>2017</span><span>,第11期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Hofe <sub xmlns =“http://www.wiley.com/namespaces/wiley”> 3 </ sub> 3（bo <sub xmlns =“http://www.wiley.com/namespaces/wiley “> 3 </ sub> 3）<sub xmlns =”http://www.wiley.com/namespaces/wiley“> 4 </ sub> 4同时高压和高温：<i xmlns =”http： //www.wiley.com/namespaces/wiley"> pupe pupe//i menp - <i xmlns =“http://www.wiley.com/namespaces/wiley”> t </ i> t相图</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061881270.html">A MicroRNA-Based Viral Strategy for Targeting and Classifying Neuron Subtypes in the Rodent Brain</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Keaveney, Marianna.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Keaveney, Marianna. </a> <span>2018</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于MicroRNA的病毒策略，用于靶向和分类啮齿动物大脑中神经元亚型</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_wiley-blackwell-online-open_thesis/040004981494.html">MicroRNA‐365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting Pax6</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jia‐Lin Mo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jia‐Lin Mo,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qi Liu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Qi Liu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zeng‐Wei Kou&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zeng‐Wei Kou,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：MicroRNA‐365通过靶向Pax6调节中风后成年大鼠大脑星形胶质细胞转化为神经元</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000131383474.html">MicroRNA-365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting Pax6</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jia-Lin Mo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jia-Lin Mo,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qi Liu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Qi Liu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zeng-Wei Kou&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zeng-Wei Kou,</a> <span>2018</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：MicroRNA-365通过靶向pax6，在中风后，将星形细胞转化为成年大鼠脑中的神经元转化为神经元</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_hebei-medical-journal_thesis/0201278389432.html">miR-375靶向Pax6基因调控视网膜母细胞瘤Y79细胞增殖凋亡的分子机制</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=桂玉敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 桂玉敏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=彭建军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,彭建军</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郭敬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郭敬</a> <span> <a href="/journal-cn-6603/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 河北医药 </a> </span> <span> . 2020</span><span>,第008期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-clinical-oncology_thesis/0201270486848.html">微小RNA-375通过靶向PAX6对宫颈癌HeLa细胞顺铂敏感性的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蒋莉莎&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 蒋莉莎</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陆义红&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陆义红</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=水丽君&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,水丽君</a> <span> <a href="/journal-cn-6204/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 临床肿瘤学杂志 </a> </span> <span> . 2018</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-clinical-experimental-medicine_thesis/0201240826460.html">靶向沉默Pax6基因表达抑制视网膜母细胞瘤增殖侵袭的机制研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=祁海燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 祁海燕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冷非&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,冷非</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=苏学刚&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,苏学刚</a> <span> <a href="/journal-cn-12940/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 临床和实验医学杂志 </a> </span> <span> . 2017</span><span>,第016期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-tissue-engineering-reconstructive-surgery_thesis/0201288789985.html">PAX6基因过表达促进大鼠骨髓内皮祖细胞向角膜内皮细胞分化</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周梦&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 周梦</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=余菲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,余菲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邵春益&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邵春益</a> <span> <a href="/journal-cn-6152/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 组织工程与重建外科杂志 </a> </span> <span> . 2021</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-medical-theory-practice_thesis/0201290227104.html">高脂饮食通过胰腺Pax6信号通路诱导妊娠大鼠胰岛素抵抗的机制</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓棋芳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邓棋芳</a> <span> <a href="/journal-cn-6675/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 医学理论与实践 </a> </span> <span> . 2021</span><span>,第013期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-40311_thesis/020222373902.html">PAX6基因2个SNPs位点与精神分裂症临床症状的相关性研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=丁玉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 丁玉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨建立&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨建立</a> <span> <a href="/conference-cn-40311/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2015天津市医学会心身医学分会学术年会 </a> <span> <span> . 2015</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315648645.html">眼发育关键基因PAX6真核表达载体构建以及PAX6/mESCs细胞系的建立</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=严会文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 严会文</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120103682901.html">PAX6基因或其表达产物在制备抑制纤维化的药物中的应用</a> <b>[P]</b> . <span> 中国专利： CN111202847A </span> <span> . 2020-05-29</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120107132966.html">PAX6在胃癌发病机制中的作用</a> <b>[P]</b> . <span> 中国专利： CN104630218A </span> <span> . 2015-05-20</span> </div> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023429685','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704023429685down" data-source="7," data-out-id="kBhmpoyj0xqQz6s02xE3xQ==," data-f-source-id="7" data-title="MicroRNA‐365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting <i xmlns='http://www.wiley.com/namespaces/wiley'>Pax6Pax6" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="23771" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="MicroRNA‐365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting <i xmlns='http://www.wiley.com/namespaces/wiley'>Pax6Pax6"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>

MicroRNA‐365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting Pax6Pax6

摘要