Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate–glutamine cycle in the tree shrew visual cortex

Sonnay Sarah; Poirot Jordan; Just Nathalie; Clerc Anne‐Catherine; Gruetter Rolf; Rainer Gregor; Duarte Jo?o M. N.

摘要

Abstract > Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (V <sub>NT</sub> ) has been proposed to couple to that of glucose utilization and of neuronal tricarboxylic acid (TCA) cycle. In this study, we tested the hypothesis that glutamatergic neurotransmission is also coupled to the TCA cycle rate in astrocytes. For that we investigated energy metabolism by means of magnetic resonance spectroscopy (MRS) in the primary visual cortex of tree shrews ( Tupaia belangeri ) under light isoflurane anesthesia at rest and during continuous visual stimulation. After identifying the activated cortical volume by blood oxygenation level‐dependent functional magnetic resonance imaging, 1 H MRS was performed to measure stimulation‐induced variations in metabolite concentrations. Relative to baseline, stimulation of cortical activity for 20?min caused a reduction of glucose concentration by ?0.34?±?0.09?μmol/g ( p ??0.001), as well as a ?9%?±?1% decrease of the ratio of phosphocreatine‐to‐creatine ( p ??0.05). Then 13 C MRS during [1,6‐ 13 C]glucose infusion was employed to measure fluxes of energy metabolism. Stimulation of glutamatergic activity, as indicated by a 20% increase of V <sub>NT</sub> , resulted in increased TCA cycle rates in neurons by 12% ( <mat:math xmlns:mat="http://www.w3.org/1998/Math/MathML" display="inline" altimg="urn:x-wiley:08941491:media:glia23259:glia23259-math-0001" xmlns:wiley="http://www.wiley.com/namespaces/wiley/wiley" wiley:location="equatio </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> >星形胶质细胞在谷氨酰胺神经传递中发挥着重要作用，即通过清除突触谷氨酸并将其转化为转移回神经元的谷氨酰胺。已经提出了该谷氨酸 - 谷氨酰胺循环（V <Sub> NT </ sub>）的速率，以耦合到葡萄糖利用和神经元三羧酸（TCA）循环的速率。在这项研究中，我们测试了谷氨酸神经递质的假设也与星形胶质细胞中的TCA循环速率相连。为此，我们通过在休息的轻的异氟醚麻醉下的树血红素（ Tupaia belangeri </ i>）中的磁共振光谱（MRS）来调查能量代谢。在休息和连续视觉刺激期间。通过血氧化水平依赖性功能磁共振成像识别活化的皮质体积，进行 1 </ sup> H mRs以测量代谢物浓度的刺激诱导的变化。相对于基线，刺激皮质活性20≤min，引起葡萄糖浓度的降低，α0.34≤0.09≤0.09Ω·ε≤0.09？磷酸氨基氨酸酯与肌酸的比例的9％？±1％降低（ p·β.<0.05）。然后采用[1,6- 13℃]葡萄糖输注期间 13 / sup> c mrs测量能量代谢的助能。刺激谷氨酸活性，如v <sub> nt </ sub>增加的20％增加，导致神经元中的TCA循环率增加12％（<mat：math xmlns：mat =“http：// www。 w3.org/1998/mathmathmath“display =”内联“altimg =”urn：x-wiley：08941491：媒体：glia23259：glia23259：glia23259-math-0001“xmlns：wiley =”http://www.wiley.com /命名空间/ wiley / wiley“wiley：location =”方程式 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-23771/'>《Glia》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共15页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sonnay Sarah&option=202" target="_blank" rel="nofollow">Sonnay Sarah;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Poirot Jordan&option=202" target="_blank" rel="nofollow">Poirot Jordan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Just Nathalie&option=202" target="_blank" rel="nofollow">Just Nathalie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Clerc Anne‐Catherine&option=202" target="_blank" rel="nofollow">Clerc Anne‐Catherine;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gruetter Rolf&option=202" target="_blank" rel="nofollow">Gruetter Rolf;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rainer Gregor&option=202" target="_blank" rel="nofollow">Rainer Gregor;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Duarte Jo?o M. N.&option=202" target="_blank" rel="nofollow">Duarte Jo?o M. N.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Laboratory for Functional and Metabolic Imaging (LIFMET)Ecole Polytechnique Fédérale de Lausanne (EPFL)Lausanne Switzerland;</p> <p>Department of Medicine Visual Cognition LaboratoryUniversity of FribourgFribourg Switzerland;</p> <p>University Hospital MünsterMünster Germany;</p> <p>Laboratory for Functional and Metabolic Imaging (LIFMET)Ecole Polytechnique Fédérale de Lausanne (EPFL)Lausanne Switzerland;</p> <p>Laboratory for Functional and Metabolic Imaging (LIFMET)Ecole Polytechnique Fédérale de Lausanne (EPFL)Lausanne Switzerland;</p> <p>Department of Medicine Visual Cognition LaboratoryUniversity of FribourgFribourg Switzerland;</p> <p>Laboratory for Functional and Metabolic Imaging (LIFMET)Ecole Polytechnique Fédérale de Lausanne (EPFL)Lausanne Switzerland;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=13 C&option=203" rel="nofollow">13 C;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cortical energy metabolism&option=203" rel="nofollow">cortical energy metabolism;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fMRI&option=203" rel="nofollow">fMRI;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=MRS&option=203" rel="nofollow">MRS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=stimulation&option=203" rel="nofollow">stimulation;</a> </p> <div class="translation"> 机译：13 c;皮质能量新陈代谢;FMRI;MRS;刺激; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023429612.html">Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate–glutamine cycle in the tree shrew visual cortex</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sonnay Sarah&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sonnay Sarah,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Poirot Jordan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Poirot Jordan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Just Nathalie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Just Nathalie,</a> <a href="/journal-foreign-23771/" target="_blank" rel="nofollow" class="tuijian_authcolor">Glia .</a> <span>2018</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：星形胶质细胞和神经元氧化代谢与树木胰蛋白酶 - 谷氨酰胺循环循环的速率相连</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704014915608.html">Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures.</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bak LK&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bak LK,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sickmann HM&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sickmann HM,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schousboe A&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Schousboe A,</a> <a href="/journal-foreign-35286/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Neuroscience Research .</a> <span>2005</span><span>,第1a2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：乳酸-丙氨酸穿梭的活性与小脑神经元-星形细胞培养物中的谷氨酸-谷氨酰胺循环活性无关。</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204116276207.html">The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sofie V. 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