Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection

Fischer Janett; Weber Alexander N. R.; Boehm Stephan; Dickhoefer Sabine; El Maadidi Souhayla; Deichsel Danilo; Knop Viola; Klinker Hartwig; Moeller Bernd; Rasenack Jens; Wang Lisa; Sharma Manu; Hinrichsen Holger; Spengler Ulrich; Buggisch Peter; Sarrazin Christoph; Pawlita Michael; Waterboer Tim; Wiese Manfred; Probst-Mueller Elsbeth; Malinverni Raffaele; Bochud Pierre-Yves; Gardiner Clair M.; OFarrelly Cliona; Berg Thomas

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Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection

机译：TLR9启动子变种对HCV感染自发性间隙的性别特异性效应

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Objective As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, TLR9 promoter polymorphisms (single nucleotide polymorphisms (SNPs)) rs187084 and rs5743836 were investigated for their effect on disease progression.

机译：目的作为病原体传感器，Toll样受体（TLR）在HCV感染期间在第一防线线中发挥作用。然而，DNA传感器TLR9对HCV感染自然过程的影响是未知的。为了解决这一点，研究了TLR9启动子多态性（单核苷酸多态性（SNP））RS187084和RS5743836以效果对疾病进展。

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《Gut: Journal of the British Society of Gastroenterology》 |2017年第10期|共9页
作者
Fischer Janett; Weber Alexander N. R.; Boehm Stephan; Dickhoefer Sabine; El Maadidi Souhayla; Deichsel Danilo; Knop Viola; Klinker Hartwig; Moeller Bernd; Rasenack Jens; Wang Lisa; Sharma Manu; Hinrichsen Holger; Spengler Ulrich; Buggisch Peter; Sarrazin Christoph; Pawlita Michael; Waterboer Tim; Wiese Manfred; Probst-Mueller Elsbeth; Malinverni Raffaele; Bochud Pierre-Yves; Gardiner Clair M.; OFarrelly Cliona; Berg Thomas;
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作者单位

Univ Hosp Dept Gastroenterol &

Rheumatol Sect Hepatol Liebigstr 21 D-04103 Leipzig Germany;

Univ Tubingen Dept Immunol Interfac Inst Cell Biol Tubingen Germany;

Univ Hosp Dept Gastroenterol &

Rheumatol Sect Hepatol Liebigstr 21 D-04103 Leipzig Germany;

Univ Tubingen Dept Immunol Interfac Inst Cell Biol Tubingen Germany;

Univ Hosp Dept Gastroenterol &

Rheumatol Sect Hepatol Liebigstr 21 D-04103 Leipzig Germany;

Univ Hosp Dept Gastroenterol &

Rheumatol Sect Hepatol Liebigstr 21 D-04103 Leipzig Germany;

Goethe Univ Hosp Frankfurt Main Med Dept 1 Frankfurt Germany;

Univ Wurzburg Dept Internal Med 2 Wurzburg Germany;

Dept Med Practice Charlottenstr 81 Berlin Germany;

Albert Ludwigs Univ Freiburg Med Dept Freiburg Germany;

Univ Tubingen Div Genet Epidemiol Inst Clin Epidemiol &

Appl Biometry Tubingen Germany;

Univ Tubingen Div Genet Epidemiol Inst Clin Epidemiol &

Appl Biometry Tubingen Germany;

Gastroenterol Schwerpunkt Praxis Dept Gastroenterol Kiel Germany;

Univ Bonn Dept Internal Med 1 Bonn Germany;

Asklepios Klin St Georg Hamburg IFI Inst Interdisciplinary Med Liver Unit Hamburg Germany;

Goethe Univ Hosp Frankfurt Main Med Dept 1 Frankfurt Germany;

German Canc Res Ctr Res Program Infect &

Canc Dept Genome Modificat &

Carcinogenesis F020;

German Canc Res Ctr Res Program Infect &

Canc Dept Genome Modificat &

Carcinogenesis F020;

Univ Hosp Dept Gastroenterol &

Rheumatol Sect Hepatol Liebigstr 21 D-04103 Leipzig Germany;

Univ Hosp Zurich Switzerland;

Pourtales Hosp Neuchatel Switzerland;

Univ Hosp Infect Dis Serv Lausanne Switzerland;

Trinity Coll Dublin Sch Biochem &

Immunol Dublin Ireland;

Trinity Coll Dublin Sch Biochem &

Immunol Dublin Ireland;

Univ Hosp Dept Gastroenterol &

Rheumatol Sect Hepatol Liebigstr 21 D-04103 Leipzig Germany;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection [J] . Fischer Janett, Weber Alexander N. R., Boehm Stephan, Gut: Journal of the British Society of Gastroenterology . 2017,第10期

机译：TLR9启动子变种对HCV感染自发性间隙的性别特异性效应
2. MBL2 Genetic Variants in HCV Infection Susceptibility, Spontaneous Viral Clearance and Pegylated Interferon Plus Ribavirin Treatment Response [J] . Zupin L., Polesello V., Alberi G., Scandinavian journal of immunology. . 2016,第1期

机译：HCV感染易感性，自发病毒清除和聚乙二醇化干扰素加利巴韦林治疗反应中的MBL2遗传变异
3. Role of interleukin 28-B in the spontaneous and treatment-related clearance of HCV infection in patients with chronic HBV/HCV dual infection. [J] . N Coppola, A Marrone, M Pisaturo, European journal of clinical microbiology and infectious diseases: Official publication of the European Society of Clinical Microbiology . 2014,第4期

机译：白细胞介素28-B在慢性HBV / HCV双重感染患者中自发和与治疗相关的HCV感染清除中的作用。
4. Safety of Peginterferon alfa-2a (PEGASYS) 180 mcg Weekly Plus Ribavirin (RBV) 800 mg Daily in HIV/HCV Coinfection Compared to HCV Monoinfection [C] . N. Brau, F.J. Torriani, M. Rodriguez Torres International AIDS Conference . 2004

机译：Peginterferon Alfa-2a（Pegasys）的安全性为180 mcg每周加上利韦韦林（RBV）800mg在HIV / HCV辛纤维中每日800毫克，与HCV单键相比
5. Enhanced pigmentation effecting decreased protein secretion and pathogenicity in spontaneous melanin variants of Gaeumannomyces graminis var tritici. [D] . Goins, Tresa Len Quoss. 1997

机译：增强的色素沉着降低了禾本科自发黑变种自发黑色素变体中的蛋白质分泌和致病性。
6. Spontaneous HCV clearance in a patient with HIV infection and a concurrent never treated evolutive HCV hepatitis after over twenty years of chronic co-infection [O] . Roberto Manfredi, Nicola Dentale, Leonardo Calza 2010

机译：经过20多年的慢性合并感染患有HIV感染并伴发从未治疗的发展性HCV肝炎患者的自发HCV清除率
7. MBL2 Genetic Variants in HCV Infection Susceptibility, Spontaneous Viral Clearance and Pegylated Interferon Plus Ribavirin Treatment Response [O] . Zupin L., Polesello V., Alberi G., 2016

机译：HCV感染易感性，自发病毒清除和聚乙二醇化干扰素加利巴韦林治疗反应中的MBL2遗传变异

Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection

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