Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

Hendrikx Tim; Duan Yi; Wang Yanhan; Oh Jee-Hwan; Alexander Laura M.; Huang Wendy; Starkel Peter; Ho Samuel B.; Gao Bei; Fiehn Oliver; Emond Patrick; Sokol Harry; van Pijkeren Jan-Peter; Schnabl Bernd

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Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

机译：细菌在肠道中产生IL-22诱导Reg3G的表达，以减少小鼠中的乙醇诱导的肝病

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Objective Antimicrobial C-type lectin regenerating islet-derived 3 gamma (REG3G) is suppressed in the small intestine during chronic ethanol feeding. Our aim was to determine the mechanism that underlies REG3G suppression during experimental alcoholic liver disease.

机译：客观抗微生物C型凝集素再生胰岛衍生的3γ（REG3G）在慢性乙醇喂养期间抑制在小肠中。我们的目的是确定在实验性酒精性肝病中抑制Reg3G抑制的机制。

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《Gut: Journal of the British Society of Gastroenterology》 |2019年第8期|共12页
作者
Hendrikx Tim; Duan Yi; Wang Yanhan; Oh Jee-Hwan; Alexander Laura M.; Huang Wendy; Starkel Peter; Ho Samuel B.; Gao Bei; Fiehn Oliver; Emond Patrick; Sokol Harry; van Pijkeren Jan-Peter; Schnabl Bernd;
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作者单位

Univ Calif San Diego Dept Med La Jolla CA 92093 USA;

Univ Calif San Diego Dept Med La Jolla CA 92093 USA;

Univ Calif San Diego Dept Med La Jolla CA 92093 USA;

Univ Wisconsin Dept Food Sci 1605 Linden Dr Madison WI 53706 USA;

Univ Wisconsin Dept Food Sci 1605 Linden Dr Madison WI 53706 USA;

Univ Calif San Diego Dept Cellular &

Mol Med La Jolla CA 92093 USA;

Catholic Univ Louvain Inst Expt &

Clin Res Lab Hepatogastroenterol Brussels Belgium;

Univ Calif San Diego Dept Med La Jolla CA 92093 USA;

Univ Calif Davis West Coast Metabol Ctr Davis CA 95616 USA;

Univ Calif Davis West Coast Metabol Ctr Davis CA 95616 USA;

Univ Tours INSERM UMR 1253 iBrain Tours France;

UPMC Univ Paris 06 Sorbonne Univ Ecole Normale Super CNRS INSERM AP HP Lab Biomol LBM Paris;

Univ Wisconsin Dept Food Sci 1605 Linden Dr Madison WI 53706 USA;

Univ Calif San Diego Dept Med La Jolla CA 92093 USA;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice [J] . Hendrikx Tim, Duan Yi, Wang Yanhan, Gut: Journal of the British Society of Gastroenterology . 2019,第8期

机译：细菌在肠道中产生IL-22诱导Reg3G的表达，以减少小鼠中的乙醇诱导的肝病
2. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and?Patients From Ethanol-Induced Liver Disease [J] . Abhishek Satishchandran, Aditya Ambade, Sitara Rao, Gastroenterology . 2018,第1期

机译：MicroRNA 122由GRLH2调节，保护小鼠的肝脏和乙醇诱导的肝病患者
3. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. [J] . Cohen JI, Roychowdhury S, McMullen MR, Gastroenterology . 2010,第2期

机译：补体和酒精性肝病：C1q在乙醇引起的小鼠肝损伤的发病机理中的作用。
4. Researches on Inducing Effects of Autoclavable IPTG and Lactose Solution on Gene Expression in Genetically Engineered Bacteria [C] . Gan Zhao, Linlin Liang, Danyun Xu, International conference on biotechnology, chemical and materials engineering . 2013

机译：高压灭菌IPTG和乳糖溶液对基因工程菌基因表达的诱导作用研究
5. Hepatocellular carcinoma and liver disease in mice with inducible oncogene expression. [D] . Boley, Patricia Anne. 2009

机译：诱导癌基因表达的小鼠肝细胞癌和肝病。
6. Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice [O] . Richa Singhal, Hridgandh Donde, Smita Ghare, 2021

机译：利用丁酸丁酯的细菌的乙酰-CoA途径减少是酒精诱导的功能性肠道微生物消除和小鼠肝病发育的关键致病特征
7. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice [O] . Tim Hendrikx, Yi Duan, Yanhan Wang, 2018

机译：在肠道中制作IL-22的细菌诱导Reg3G的表达，以降低小鼠乙醇诱导的肝病

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

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