Advances in oral delivery of anti-cancer prodrugs

摘要

Cancer is considered as the leading cause of morbidity and mortality worldwide, accounting about 8.2 million deaths in 2012. The recent data from World Health Organization (WHO) suggest the prevalence of 14 million new cases in 2012 that will rise to 22 million in next two decades [1]. Physiologically complex and dynamic environment of cancer raises several critical challenges for its safe and effective treatment [2], Considering the chronic dosage regimen in cancer therapy, oral administration of chemotherapeutic drugs is always considered to be a preferred route as compared to their conven-tional intravenous injection