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Biodegradable synthetic polyesters in the technology of controlled dosage forms of arttihypertensive drugs - the overview

机译:可生物降解的合成聚酯在艺术化药物控制剂型技术中 - 概述

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ABSTRACT Introduction: Arterial hypertension is a disease of civilization that requires long-term treatment. Recently, growing interest in natural and synthetic polymers as drug delivery vehicles in controlled release dosage forms for improving the efficacy of treatment has been observed. Areas covered: This review introduces biodegradable synthetic polyesters as macromolecular carriers of antihypertensive drugs. Although various, synthetic and natural polymer-drug conjugates and/or polymeric carriers of anticancer drugs are currently under preclinical and clinical studies, there is no such data for antihypertensive drugs. Therefore, it seems appropriate to use such materials for the treatment of hypertension. Expert opinion: There are currently only a few studies describing the use of synthetic polyesters in the arterial hypertension therapy. In order to the fact that there is a high demand for new, effective antihypertensive dosage forms, further studies for such drug carriers are certainly expected. Synthetic polyester carriers could improve the drug bioavailability and its pharmacokinetic properties by altering the pharmaceutical dosage form. This property is particularly useful for drugs with proven pharmacological action, but with limited application due to their inappropriate pharmacological properties. The development of new polymeric materials and technologies affords the opportunity to produce novel synthetic polyester DDSs.
机译:摘要介绍:动脉高压是一种文明疾病,需要长期治疗。最近,已经观察到,对于用于改善治疗效果的控制释放剂型中的药物递送载体,对天然和合成聚合物的兴趣日益增长。涵盖了地区:本报告介绍了可生物降解的合成聚酯作为抗高血压药物的大分子载体。虽然目前在临床前和临床研究的各种,合成和天然聚合物 - 药物缀合物和/或聚合物载体的抗高血压药物的数据。因此,使用这些材料用于治疗高血压似乎是合适的。专家意见:目前只有一些研究描述了在动脉高压治疗中使用合成聚酯。为了使新的有效抗高血压剂型的需求很高,肯定会预期这种药物载体的进一步研究。通过改变药物剂型,合成聚酯载体可以改善药物生物利用度及其药代动力学性能。该物业对验证药理作用的药物特别有用,但由于其不适当的药理学特性,应用有限。新型聚合物材料和技术的发展提供了生产新颖的合成聚酯DDSS的机会。

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