Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer

DeWitt John M.; Sandrasegaran Kumar; ONeil Bert; House Michael G.; Zyromski Nicholas J.; Sehdev Amikar; Perkins Susan M.; Flynn Janet; McCranor Lynne; Shahda Safi

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Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer

机译：局部引导光动力治疗局部晚期胰腺癌的第1阶段研究

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Background and Aims: Locally advanced pancreatic cancer (LAPC) has a poor prognosis. There are limited data describing the use of photodynamic therapy (PDT) for pancreatic cancer in humans. We hypothesized that EUS-guided PDT for LAPC is safe, technically feasible, and produces a dose- and time-dependent increasing degree of image-defined tumor necrosis.

机译：背景和宗旨：局部晚期的胰腺癌（LAPC）预后差。有限的数据描述了对人类的胰腺癌使用光动力治疗（PDT）。我们假设用于LAPC的EUS引导的PDT是安全的，技术上可行的，并产生一种剂量和时间依赖性增加的图像定义肿瘤坏死程度。

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来源
《Gastrointestinal Endoscopy》 |2019年第2期|共9页
作者
DeWitt John M.; Sandrasegaran Kumar; ONeil Bert; House Michael G.; Zyromski Nicholas J.; Sehdev Amikar; Perkins Susan M.; Flynn Janet; McCranor Lynne; Shahda Safi;
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Indiana Univ Dept Gastroenterol Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Radiol Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Oncol Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Surg Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Surg Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Oncol Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Stat Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Oncol Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Oncol Hlth Med Ctr Indianapolis IN 46202 USA;

Indiana Univ Dept Oncol Hlth Med Ctr Indianapolis IN 46202 USA;

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正文语种 eng
中图分类消化系及腹部疾病;
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专利

1. Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer [J] . DeWitt John M., Sandrasegaran Kumar, ONeil Bert, Gastrointestinal Endoscopy . 2019,第2期

机译：局部引导光动力治疗局部晚期胰腺癌的第1阶段研究
2. Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer [J] . M T Huggett, M Jermyn, A Gillams, British Journal of Cancer . 2014,第7期

机译：Verteporfin光动力疗法在局部晚期胰腺癌中的I / II期研究
3. An open-label, single-arm pilot study of EUS-guided brachytherapy with phosphorus-32 microparticles in combination with gemcitabine plus /- nab-paclitaxel in unresectable locally advanced pancreatic cancer (OncoPaC-1): Technical details and study protocol [J] . Progress in Artificial Intelligence . 2020,第1期

机译：具有磷-32微粒的EUS引导的近距离放射治疗的开放式标签，与吉西滨加/ - 腹泻组合在不可切除的局部晚期胰腺癌中（ONCOPAC-1）：技术细节和研究方案
4. Photodynamic therapy of locally advanced pancreatic cancer (VERTPAC study): final clinical results [C] . Huggett MT, Jermyn M, Gillams A, Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXII . 2013

机译：局部晚期胰腺癌的光动力疗法（VERTPAC研究）：最终临床结果
5. Chlorin-e6 loaded mesoporous silica nanoparticles for photodynamic therapy of pancreatic cancer [D] . Atre, Anup M. 2017

机译：负载氯霉素-e6的中孔二氧化硅纳米粒子用于胰腺癌的光动力治疗
6. Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer [O] . M T Huggett, M Jermyn, A Gillams, 2014

机译：Verteporfin光动力疗法在局部晚期胰腺癌中的I / II期研究
7. Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer [O] . M T Huggett, M Jermyn, A Gillams, 2014

机译：临床胰腺癌中Verteporfin光动力治疗的I / II研究

Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer

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