Pancreatic cancer screening in high-risk individuals with germline genetic mutations

Davee Tomas; Coronel Emmanuel; Papafragkakis Charilaos; Thaiudom Sayam; Lanke Gandhi; Chakinala Raja C.; Gonzalez Graciela M. Nogueras; Bhutani Manoop S.; Ross William A.; Weston Brian R.; Lee Jeffrey H.

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Pancreatic cancer screening in high-risk individuals with germline genetic mutations

机译：胰腺癌筛选在具有种系遗传突变的高危人物中

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Background and Aims: Pancreatic cancer (PC) is a deadly disease that is most commonly diagnosed at an incurable stage. Different high-risk genetic variants and cancer syndromes increase the lifetime risk of developing PC. This study aims to assess the yield of initial PC screening in patients with high-risk germline mutations.

机译：背景和目的：胰腺癌（PC）是一种致命的疾病，最常见于无法治愈的阶段。不同的高风险遗传变异和癌症综合征增加了开发PC的寿命风险。本研究旨在评估高危种系突变患者初始PC筛选的产量。

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《Gastrointestinal Endoscopy》 |2018年第6期|共8页
作者
Davee Tomas; Coronel Emmanuel; Papafragkakis Charilaos; Thaiudom Sayam; Lanke Gandhi; Chakinala Raja C.; Gonzalez Graciela M. Nogueras; Bhutani Manoop S.; Ross William A.; Weston Brian R.; Lee Jeffrey H.;
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作者单位

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Biostat Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Gastroenterol Hepatol &

Nutr Houston TX 77030 USA;

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正文语种 eng
中图分类消化系及腹部疾病;
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专利

1. Pancreatic cancer screening in high-risk individuals with germline genetic mutations [J] . Davee Tomas, Coronel Emmanuel, Papafragkakis Charilaos, Gastrointestinal Endoscopy . 2018,第6期

机译：胰腺癌筛选在具有种系遗传突变的高危人物中
2. Outcome of Pancreatic Cancer Surveillance Among High-Risk Individuals Tested for Germline Mutations in BRCA1 and BRCA2 [J] . Saldia Amethyst, Olson Sara H., Nunes Pamela, Cancer prevention research. . 2019,第9期

机译：在BRCA1和BRCA2检测在种系突变中检测的高危个体胰腺癌监测结果
3. EUS and MRI/MRCP Findings in Pancreatic Cancer Screening for Individuals Who Harbor a BRCA2 Deleterious Germline Mutation [J] . Hosmer Amy, Merajver Sofia, Stoffel Elena, The American Journal of Gastroenterology . 2016,第Suppla1期

机译：EUS和MRI / MRCP在胰腺癌筛查中发现携带BRCA2有害生殖细胞突变的个体
4. GERMLINE AND SOMATIC MUTATIONS OF APC GENE AND THE GENOTYPE-PHENOTYPE ANALYSIS IN FAP AND SPORADIC COLORECTAL CANCERS [C] . Xiaorong Liu, Department of Genetics, Xiangnian Shan, 第四届国际后基因组生命科学技术学术论坛 . 2006

机译：FAP和散发性大肠癌中APC基因的种系和体细胞突变以及基因型-表型分析
5. Characterization of germline CHEK2 mutations in African-American women at high risk for hereditary breast cancer. [D] . Hill, Janell Glennette. 2009

机译：遗传性乳腺癌高风险的非裔美国女性生殖系CHEK2突变的表征。
6. Multiple rare variants in high-risk pancreatic cancer related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations [O] . Xiaohong R. Yang, Melissa Rotunno, Yanzi Xiao, -1

机译：高危胰腺癌相关基因中的多个罕见变体可能会增加和不发生种系CDKN2A突变的部分患者发生胰腺癌的风险
7. Pancreatic cancer screening in high-risk individuals with germline genetic mutations [O] . Tomas DaVee, Emmanuel Coronel, Charilaos Papafragkakis, 2018

机译：胰腺癌筛选在具有种系遗传突变的高危人物中
8. Screening for Novel Germline Rare Mutations Associated with Aggressive Prostate Cancer. [R] . 2015

机译：筛选与侵袭性前列腺癌相关的新型种系稀有突变。

Pancreatic cancer screening in high-risk individuals with germline genetic mutations

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