Effects of EUS-guided intratumoral injection of oligonucleotide STNM01 on tumor growth, histology, and overall survival in patients with unresectable pancreatic cancer

Nishimura Makoto; Matsukawa Miho; Fujii Yuko; Matsuda Yoko; Arai Tomio; Ochiai Yasutoshi; Itoi Takao; Yahagi Naohisa

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Effects of EUS-guided intratumoral injection of oligonucleotide STNM01 on tumor growth, histology, and overall survival in patients with unresectable pancreatic cancer

机译：脱核核苷酸STNM01对不可切征胰腺癌患者肿瘤生长，组织学和整体存活的影响

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Background and Aims: Carbohydrate sulfotransferase 15 (CHST15) promotes tumor growth and invasion and is considered to be an emergent therapeutic target for pancreatic cancer. The aim of this study was to evaluate the safety and efficacy of EUS-guided fine-needle injection (EUS-FNI) of STNM01, the double-stranded RNA oligonucleotide that specifically represses CHST15, for use in patients with pancreatic cancer.

机译：背景和目的：碳水化合物磺基转移酶15（CHST15）促进肿瘤生长和侵袭，被认为是胰腺癌的紧急治疗靶标。本研究的目的是评估STNM01的EUS引导的细针注射（EUS-FNI）的安全性和功效，特别是抑制CHST15的双链RNA寡核苷酸，用于胰腺癌的患者。

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《Gastrointestinal Endoscopy》 |2018年第4期|共6页
作者
Nishimura Makoto; Matsukawa Miho; Fujii Yuko; Matsuda Yoko; Arai Tomio; Ochiai Yasutoshi; Itoi Takao; Yahagi Naohisa;
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作者单位

Tokyo Metropolitan Geriatr Hosp &

Inst Gerontol Dept Gastrointestinal Endoscopy Tokyo Japan;

Tokyo Metropolitan Geriatr Hosp &

Inst Gerontol Dept Gastrointestinal Endoscopy Tokyo Japan;

Tokyo Metropolitan Geriatr Hosp &

Inst Gerontol Dept Gastrointestinal Endoscopy Tokyo Japan;

Tokyo Metropolitan Geriatr Hosp &

Inst Gerontol Dept Pathol Tokyo Japan;

Tokyo Metropolitan Geriatr Hosp &

Inst Gerontol Dept Pathol Tokyo Japan;

Keio Univ Hosp Ctr Canc Div Res &

Dev Minimally Invas Treatment Tokyo Japan;

Tokyo Med Univ Dept Gastroenterol &

Hepatol Tokyo Japan;

Keio Univ Hosp Ctr Canc Div Res &

Dev Minimally Invas Treatment Tokyo Japan;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Effects of EUS-guided intratumoral injection of oligonucleotide STNM01 on tumor growth, histology, and overall survival in patients with unresectable pancreatic cancer [J] . Nishimura Makoto, Matsukawa Miho, Fujii Yuko, Gastrointestinal Endoscopy . 2018,第4期

机译：脱核核苷酸STNM01对不可切征胰腺癌患者肿瘤生长，组织学和整体存活的影响
2. Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer [J] . N Hanna, P Ohana, F M Konikoff, Cancer gene therapy . 2012,第6期

机译：不可切除胰腺癌患者肿瘤内给药BC-819的1 / 2a期，剂量递增，安全性，药代动力学和初步疗效研究
3. Computed Tomography Demonstration of the Production and Distribution of Oxygen Gas Following Intratumoral Injection of a New Radiosensitizer (KORTUC) for Patients with Breast Cancer—Is Intratumoral Injection Not an Ideal Approach to Solve the Major Problem of Tumor Hypoxia in Radiotherapy? [J] . Naoya Hayashi, Yasuhiro Ogawa, Kei Kubota, Cancers . 2016,第4期

机译：肿瘤内注射新型放射增敏剂（KORTUC）对乳腺癌患者的氧气产生和分布的计算机断层扫描演示—肿瘤内注射不是解决放射疗法中肿瘤缺氧的主要方法的理想方法吗？
4. Effect of Intrahepatic Arterial and Intraportal Administration of FK506 on Liver Transplantation Survival for Unresectable Progressive Liver Cancer and Possible Prevention of Tumor Recurrence in Rats [C] . K. Yano, R. Sumimoto, Y. Fukuda, European Society for Surgical Research . 2006

机译：FK506肝内动脉和内部施用对肝移植肝癌肝移植存活的影响及可能预防大鼠肿瘤复发
5. APE1/Ref-1 Redox Signaling Regulates HIF1a-Mediated CA9 Expression in Hypoxic Pancreatic Cancer Cells: Combination Treatment in Patient-Derived Pancreatic Tumor Models [D] . Logsdon, Derek Paul. 2018

机译：APE1 / Ref-1氧化还原信号调节低氧胰腺癌细胞中HIF1a介导的CA9表达：患者源性胰腺肿瘤模型的联合治疗
6. A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus HF10 for unresectable locally advanced pancreatic cancer [O] . Yoshiki Hirooka, Hideki Kasuya, Takuya Ishikawa, 2018

机译：EUS指导的瘤内注射溶瘤病毒HF10的I期临床试验用于不可切除的局部晚期胰腺癌
7. Figure 7.5.b.1 Survival of patients with MCN after pancreatectomy according to the histological classification Figure 7.5.b.2 Survival of patients with MCN after pancreatectomy according to cancer-stroma relationship Figure 7.5.b.3 Survival of patients with MCN after pancreatectomy according to growth patterns of tumors infiltrating surrounding tissue Figure 7.5.b.4 Survival of patients with MCN after pancreatectomy according to lymphatic invasion Figure 7.5.b.5 Survival of patients with MCN after pancreatectomy according to venous invasion Figure 7.5.b.6 Survival of patients with MCN after pancreatectomy according to intrapancreatic nerve invasion Figure 7.5.b.7 Survival of patients with MCN after pancreatectomy according to Spread within the main pancreatic duct [O] . 2007

机译：图7.5.B.1根据组织学分类，胰腺切除术后MCN患者的存活图7.5.B.2根据癌基质关系，胰腺切除后MCN患者的存活图7.5.B.3生存根据胰岛切除术后MCN患者的肿瘤渗透围绕组织的生长模式图7.5.B.4根据淋巴侵入胰腺切除术后MCN患者的存活图7.5.B.5胰岛切除后MCN患者的存活对于静脉侵袭图7.5.b.6根据脑切除术后的MCN患者的存活术根据脑内神经侵袭图7.5.B.7胰岛切除术后MCN患者的存活率根据主要的胰腺管道内的蔓延

Effects of EUS-guided intratumoral injection of oligonucleotide STNM01 on tumor growth, histology, and overall survival in patients with unresectable pancreatic cancer

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