Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status

Sugai Tamotsu; Eizuka Makoto; Arakawa Noriyuki; Osakabe Mitsumasa; Habano Wataru; Fujita Yasuko; Yamamoto Eiichiro; Yamano Hiroo; Endoh Masaki; Matsumoto Takayuki; Suzuki Hiromu

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Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status

机译：基于微卫星状态的胃膜瘤瘤中体细胞拷贝数改变的分子剖析及综合基因组分析

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We attempted to identify the molecular profiles of gastric intramucosal neoplasia (IMN; low-grade dysplasia, LGD; high-grade dysplasia, HGD; intramucosal cancer, IMC) by assessing somatic copy number alterations (SCNAs) stratified by microsatellite status (microsatellite stable, MSS; microsatellite instable, MSI). Thus, microsatellite status was determined in 84 tumors with MSS status and 16 tumors with MSI status.

机译：我们试图通过评估通过微卫星状态分层的体细胞拷贝数改变（SCNA），鉴定胃暗层肿瘤瘤瘤（IMN;低级发育不良，LGD;高级发育不良，HGD; Intramucess Cance，IMC）的分子剖面。通过微卫星状态分层（微卫星稳定， MSS;微卫星稳定，MSI）。因此，在84例肿瘤中测定微卫星状态，MSS状态和16个肿瘤，具有MSI状态。

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《Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association》 |2018年第5期|共11页
作者
Sugai Tamotsu; Eizuka Makoto; Arakawa Noriyuki; Osakabe Mitsumasa; Habano Wataru; Fujita Yasuko; Yamamoto Eiichiro; Yamano Hiroo; Endoh Masaki; Matsumoto Takayuki; Suzuki Hiromu;
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作者单位

Iwate Med Univ Sch Med Dept Mol Diagnost Pathol 19-1 Uchimaru Morioka Iwate 0208505 Japan;

Iwate Med Univ Sch Med Dept Mol Diagnost Pathol 19-1 Uchimaru Morioka Iwate 0208505 Japan;

Iwate Med Univ Sch Med Dept Mol Diagnost Pathol 19-1 Uchimaru Morioka Iwate 0208505 Japan;

Iwate Med Univ Sch Med Dept Mol Diagnost Pathol 19-1 Uchimaru Morioka Iwate 0208505 Japan;

Iwate Med Univ Sch Pharm Dept Pharmacodynam &

Mol Genet 19-1 Uchimaru Morioka Iwate 0208505;

Iwate Med Univ Sch Med Dept Mol Diagnost Pathol 19-1 Uchimaru Morioka Iwate 0208505 Japan;

Sapporo Med Univ Sch Med Dept Mol Biol Cyuuou Ku Sapporo Hokkaido 0600061 Japan;

Sapporo Med Univ Sch Med Dept Gastroenterol Cyuuou Ku Sapporo Hokkaido 0600061 Japan;

Iwate Med Univ Sch Med Dept Internal Med Div Gastroenterol 19-1 Uchimaru Morioka Iwate;

Iwate Med Univ Sch Med Dept Internal Med Div Gastroenterol 19-1 Uchimaru Morioka Iwate;

Sapporo Med Univ Sch Med Dept Mol Biol Cyuuou Ku Sapporo Hokkaido 0600061 Japan;

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正文语种 eng
中图分类肿瘤学;
关键词
Comprehensive genomic analysis; Copy number alteration; Gastric intramucosal neoplasia; Microsatellite instability; Mutation;

机译：综合基因组分析;拷贝数改变;胃膜瘤形成;微卫星不稳定性;突变;

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专利

1. Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status [J] . Sugai Tamotsu, Eizuka Makoto, Arakawa Noriyuki, Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association . 2018,第5期

机译：基于微卫星状态的胃膜瘤瘤中体细胞拷贝数改变的分子剖析及综合基因组分析
2. Molecular profiling and genome‐wide analysis based on somatic copy number alterations in advanced colorectal cancers [J] . Sugai Tamotsu, Takahashi Yayoi, Eizuka Makoto, Molecular Carcinogenesis . 2018,第3期

机译：基于晚期结直肠癌的体细胞拷贝数改变的分子分析和基因组分析
3. Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia [J] . Tatsuo Hata, Masaya Suenaga, Luigi Marchionni, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2018,第7期

机译：基因组 - 高级胰腺上皮内肿瘤中的全身体细胞拷贝数改变和突变
4. Somatic Copy Number Alteration-Based Prediction of Molecular Subtypes of Breast Cancer Using Deep Learning Model [C] . Md. Mohaiminul Islam, Rasif Ajwad, Chen Chi, Canadian conference on artificial intelligence . 2017

机译：基于深度学习模型的基于体细胞拷贝数变化的乳腺癌分子亚型预测
5. The Analysis of Somatic Copy Number Alteration in Human Cancers [D] . Mermel, Craig Harold 2010

机译：人类癌症中体细胞拷贝数变化的分析
6. Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status [O] . Tamotsu Sugai, Makoto Eizuka, Noriyuki Arakawa, -1

机译：基于微卫星状态的胃黏膜内瘤变的体细胞拷贝数变化的分子谱分析和全基因组全范围分析
7. Comprehensive molecular analysis based on somatic copy number alterations in intramucosal colorectal neoplasias and early invasive colorectal cancers [O] . Tamotsu Sugai, Makoto Eizuka, Wataru Habano, 2018

机译：基于体细胞拷贝数改变的综合分子分析结直肠癌和早期侵入性结直肠癌

Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status

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