Apple Allergy-Development of Tolerance Through Regular Consumption of Low-Allergen Apples. An Observational Study

摘要

Pollen-associated oral allergy syndrome (OAS) is a special form of IgE-mediated food allergies. Especially with birch pollen allergy sufferers, due to the similarity of the epitopes of the apple allergen Mal d 1 and the birch pollen allergen Bet v 1, there is often a so-called cross-reaction when eating commercially available supermarket apples. In a prospective cohort study with an open study design, it was examined whether tolerance development in "apple allergy sufferers" can be achieved through regular consumption of low-allergen apples. For this purpose, the expression of oral symptoms after eating a fruit of the variety 'Golden Delicious' before and after daily consumption of an allergen-poor apple for 90 days was examined. The subjects showed significantly less symptoms when eating the 'Golden Delicious' after regular consumption of the low-allergen apples of old varieties. It appears possible to achieve an oral tolerance to highly allergenic apples through regular consumption of old varieties with a lower allergen content.