Metabolic activation of prohaptens in a modified KeratinoSens assay using rat liver S9 (cytosolic) fraction spiked with cutaneous cytochrome P450s

Huth L.; Huth S.; Karlberg A. T.; Baron J. M.; Merk H. F.

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Metabolic activation of prohaptens in a modified KeratinoSens assay using rat liver S9 (cytosolic) fraction spiked with cutaneous cytochrome P450s

机译：使用大鼠肝脏S9（胞质溶胶）分数用皮肤细胞色素P450s掺入改性角蛋白酶测定中PROHaptens的代谢活化

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来源
《Experimental dermatology》 |2017年第3期|共1页
作者
Huth L.; Huth S.; Karlberg A. T.; Baron J. M.; Merk H. F.;
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作者单位

Rhein Westfal TH Aachen Dept Dermatol &

Allergol Aachen Germany;

Rhein Westfal TH Aachen Dept Dermatol &

Allergol Aachen Germany;

Univ Gothenburg Inst Skin Chem Gothenburg Sweden;

Rhein Westfal TH Aachen Dept Dermatol &

Allergol Aachen Germany;

Rhein Westfal TH Aachen Dept Dermatol &

Allergol Aachen Germany;

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原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;
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1. Metabolic activation of prohaptens in a modified KeratinoSens assay using rat liver S9 (cytosolic) fraction spiked with cutaneous cytochrome P450s [J] . Huth L., Huth S., Karlberg A. T., Experimental dermatology . 2017,第3期

机译：使用大鼠肝脏S9（胞质溶胶）分数用皮肤细胞色素P450s掺入改性角蛋白酶测定中PROHaptens的代谢活化
2. 3-Aminobenzanthrone, a Human Metabolite of the Environmental Pollutant 3-Nitrobenzanthrone, Forms DNA Adducts after Metabolic Activation by Human and Rat Liver Microsomes: Evidence for Activation by Cytochrome P450 1A1 and P450 1A2. [J] . Stiborova M Chemical research in toxicology . 2004,第8期

机译：3-氨基苯并蒽醌，一种环境污染物3-硝基苯并蒽醌，在人和大鼠肝微粒体代谢激活后形成DNA加合物：细胞色素P450 1A1和P450 1A2激活的证据。
3. Metabolic activation of bisphenol A by rat liver S9 fraction. [J] . Yoshihara S, Makishima M, Suzuki N, Toxicological sciences: An official journal of the Society of Toxicology . 2001,第2期

机译：大鼠肝脏S9组分对双酚A的代谢活化。
4. Mass spectrometry- based assay for absolute quantification of cytochromes P450 in human liver [C] . Schnabel A., Langenfeld E., Serschnitzki B., International Conference on Cytochrome P450 . 2009

机译：基于质谱的基于质谱 - 用于人肝中细胞色素P450的绝对定量的测定
5. High-throughput cytochrome P450 catalysis: Exploiting an array-based platform for cytotoxicity, inhibition, metabolism, permeability, and metabolic stability assays [D] . Sukumaran, Sumitra Meena 2009

机译：高通量细胞色素P450催化：利用基于阵列的平台进行细胞毒性，抑制，代谢，通透性和代谢稳定性测定
6. Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability [O] . Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni, -1

机译：药物发现的效率：肝S9分数测定作为代谢稳定性的筛选
7. Utility of Rat Liver S9 Fractions to Study Skin-Sensitizing Prohaptens in a Modified KeratinoSens Assay [O] . Andreas Natsch, Tina Haupt 2013

机译：大鼠肝脏S9分数研究修饰角蛋白酶测定中皮肤致敏Prohaptens的效用
8. Results of an Ames Test Conducted in Salmonella Typhimurium Tester Strain TA98 in the Presence of S9 (Aroclorinduced Rat Liver S9) Metabolic Activation with Mixture of Substituted Nitrogen-Containing Heterocyclic Compounds. [R] . 2009

机译：在存在s9（aroclor诱导的大鼠肝s9）代谢活化的鼠伤寒沙门氏菌测试菌株Ta98中进行的ames试验的结果，其中含有取代的含氮杂环化合物的混合物。

Metabolic activation of prohaptens in a modified KeratinoSens assay using rat liver S9 (cytosolic) fraction spiked with cutaneous cytochrome P450s

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