Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

Na Rong; Zheng S. Lilly; Han Misop; Yu Hongjie; Jiang Deke; Shah Sameep; Ewing Charles M.; Zhang Liti; Novakovic Kristian; Petkewicz Jacqueline; Gulukota Kamalakar; Helseth Donald L. Jr.; Quinn Margo; Humphries Elizabeth; Wiley Kathleen E.; Isaacs Sarah D.; Wu Yishuo; Liu Xu; Zhang Ning; Wang Chi-Hsiung; Khandekar Janardan; Hulick Peter J.; Shevrin Daniel H.; Cooney Kathleen A.; Shen Zhoujun; Partin Alan W.; Carter H. Ballentine; Carducci Michael A.; Eisenberger Mario A.; Denmeade Sam R.; McGuire Michael; Walsh Patrick C.; Helfand Brian T.; Brendler Charles B.; Ding Qiang; Xu Jianfeng; Isaacs William B.

首页> 外文期刊>European urology >Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

【24h】

Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

机译：ATM和BRCA1 / 2中的种系突变区分致死和惰性前列腺癌的风险，并与死亡的休眠有关

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Background: Germline mutations in BRCA1/2 and ATM have been associated with prostate cancer (PCa) risk. Objective: To directly assess whether germline mutations in these three genes distinguish lethal from indolent PCa and whether they confer any effect on age at death.

机译：背景：BRCA1 / 2和ATM中的种系突变与前列腺癌（PCA）风险有关。目的：直接评估这三种基因中的种系突变是否区分惰性PCA，以及它们是否对死亡年龄的任何影响。

著录项

来源
《European urology》 |2017年第5期|共8页
作者
Na Rong; Zheng S. Lilly; Han Misop; Yu Hongjie; Jiang Deke; Shah Sameep; Ewing Charles M.; Zhang Liti; Novakovic Kristian; Petkewicz Jacqueline; Gulukota Kamalakar; Helseth Donald L. Jr.; Quinn Margo; Humphries Elizabeth; Wiley Kathleen E.; Isaacs Sarah D.; Wu Yishuo; Liu Xu; Zhang Ning; Wang Chi-Hsiung; Khandekar Janardan; Hulick Peter J.; Shevrin Daniel H.; Cooney Kathleen A.; Shen Zhoujun; Partin Alan W.; Carter H. Ballentine; Carducci Michael A.; Eisenberger Mario A.; Denmeade Sam R.; McGuire Michael; Walsh Patrick C.; Helfand Brian T.; Brendler Charles B.; Ding Qiang; Xu Jianfeng; Isaacs William B.;
展开▼
作者单位

Fudan Univ Huashan Hosp Fudan Inst Urol Shanghai Peoples R China;

Program Isaacs Personalized Canc Care Evanston IL USA;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

NorthShore Univ HealthSyst Dept Ctr Mol Med Evanston IL USA;

NorthShore Univ HealthSyst Dept Ctr Mol Med Evanston IL USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Fudan Univ Huashan Hosp Fudan Inst Urol Shanghai Peoples R China;

Program Isaacs Personalized Canc Care Evanston IL USA;

Fudan Univ Huashan Hosp Fudan Inst Urol Shanghai Peoples R China;

Program Isaacs Personalized Canc Care Evanston IL USA;

NorthShore Univ HealthSyst Dept Ctr Mol Med Evanston IL USA;

NorthShore Univ HealthSyst Dept Med Evanston IL USA;

Fudan Univ Huashan Hosp Fudan Inst Urol Shanghai Peoples R China;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

Johns Hopkins Med Inst Sidney Kimmel Comprehens Canc Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Sidney Kimmel Comprehens Canc Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Sidney Kimmel Comprehens Canc Ctr Baltimore MD 21205 USA;

NorthShore Univ HealthSyst Dept Surg Evanston IL USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

Program Isaacs Personalized Canc Care Evanston IL USA;

Fudan Univ Huashan Hosp Fudan Inst Urol Shanghai Peoples R China;

Fudan Univ Huashan Hosp Fudan Inst Urol Shanghai Peoples R China;

Johns Hopkins Univ Sch Med Dept Urol Baltimore MD 21205 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Lethal prostate cancer; Germline; Mutation; DNA repair genes;

机译：致死的前列腺癌;种系;突变;DNA修复基因;

相似文献

外文文献
中文文献
专利

1. 积极监测是区分致死性与非致死性前列腺癌亚型的可行方法 [J] . Yoshiyuki Kakehi 亚洲男性学杂志：英文版 . 2012,第003期
2. 新型雄激素受体种系错义突变与非裔男性家族性前列腺癌 [J] . Si-Yi Hu, Tao Liu, Zhen-Zhen Liu, 亚洲男性学杂志：英文版 . 2010,第003期
3. Re: Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death Editorial Comment [J] . Taneja Samir S. The Journal of Urology . 2017,第4期

机译：Re：ATM和BRCA1 / 2中的种系突变区分致死性和惰性前列腺癌的风险，并与死亡的早期有关编辑评论
4. Average age-specific cumulative risk of breast cancer according to type and site of germline mutations in BRCA1 and BRCA2 estimated from multiple-case breast cancer families attending Australian family cancer clinics. [J] . Scott CL, Jenkins MA, Southey MC, Human Genetics . 2003,第5a6期

机译：根据在澳大利亚家庭癌症诊所就诊的多例乳腺癌家庭估计的BRCA1和BRCA2生殖系突变的类型和部位，乳腺癌的平均年龄特定累积风险。
5. Re: Germline Mutations in ATM and BRCA1/2 are Associated with Grade Reclassification in Men on Active Surveillance for Prostate Cancer [J] . Taneja Samir S. The Journal of Urology . 2019,第5期

机译：Re：ATM和BRCA1 / 2中的种系突变与男性的等级重新分类有关，用于前列腺癌的积极监测
6. An Integrated Microfluidic Platform for Detecting BRCA1/BRCA2 Gene Mutation and Risk Assessment of Ovarian Cancer [C] . Yu-Hung Cheng, Chih-Hung Wang, Keng-Fu Hsu, International Conference on Solid-State Sensors, Actuators and Microsystems . 2021

机译：一种用于检测BRCA1 / BRCA2基因突变和卵巢癌风险评估的集成微流体平台
7. Segregation analyses in Ashkenazi Jewish families: Evidence of an additional breast cancer susceptibility gene, and evaluation of cancer risks in BRCA1/2 mutation carriers. [D] . Kaufman, David J. 2002

机译：阿什肯纳兹犹太人家庭的隔离分析：另一个乳腺癌易感基因的证据，以及BRCA1 / 2突变携带者的癌症风险评估。
8. Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death [O] . Rong Na, S. Lilly Zheng, Misop Han, -1

机译：ATM和BRCA1 / 2中的种系突变可区分致死性和惰性前列腺癌的风险并与死亡早期有关
9. Germline BRCA1 mutations increase prostate cancer risk [O] . Leongamornlert, D, Mahmud, N, Tymrakiewicz, M, 2012

机译：生殖系BRCA1突变增加前列腺癌的风险

Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

摘要

著录项

相似文献

相关主题

期刊订阅