The Effect of Alcohol on Sirtl Expression and Function in Animal and Human Models of Hepatocellular Carcinoma (HCC)

摘要

Introduction: Chronic heavy alcohol use is an independent risk factor for developing hepatocellular carcinoma (HCC). Sirtuin-1 (Sirtl) is a NAD~+-dependent deacetylase implicated in alcohol-induced liver injury and overexpressed in human HCC. The aims of this study were to investigate Sirtl expression in mouse models of HCC and chronic EtOH-feeding, and in human HCC cells expressing alcohol metabolizing enzymes.